{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:15:44Z","timestamp":1726186544298},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Asymptomatic novel CORonavirus iNfection (ACORN) study was designed to investigate the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in the asymptomatic adult population of the Indianapolis metropolitan area, to follow individuals testing positive for the development of symptoms, and to understand duration of positive test results. ACORN is a cross\u2010sectional community\u2010based observational study of adult residents presenting asymptomatic for COVID\u2010like illness, defined as the self\u2010reported absence of the following three symptoms in the last 7 days: fever (\u2265100\u00b0F), new\u2010onset or worsening cough, and new\u2010onset or worsening shortness of breath. SARS\u2010CoV\u20102 infection was determined by real\u2010time reverse transcription\u2010polymerase chain reaction in nasopharyngeal swab samples. SARS\u2010CoV\u20102 infection prevalence was expressed as a point estimate with 95% confidence interval (CI). Test results are reported for 2953 participants who enrolled and underwent nasopharyngeal swab testing between 7 April 2020 and 16 May 2020. Among tested participants, 91 (3.1%; 95% CI: 2.5%\u20103.7%) were positive for SARS\u2010CoV\u20102. Overall, baseline characteristics, medical history, and infection risk factors were comparable between SARS\u2010CoV\u20102 positive and negative participants. Within the ongoing 14\u2010day follow\u2010up period for positive participants, 58 (71.6%) of 81 assessed participants remained asymptomatic while others (n\u2009=\u200923, 28.4%) reported one or more symptoms. Indiana had \u201cStay\u2010at\u2010Home\u201d orders in place during nearly the entire test period reported here, yet 3.1% of asymptomatic participants tested positive for SARS\u2010CoV\u20102. These results indicate screening questions had limited predictive utility for testing in an asymptomatic population and suggest broader testing strategies are needed. Importantly, these findings underscore that more research is needed to understand the viral transmission and the role asymptomatic and presymptomatic individuals play in this global pandemic.<\/jats:p>","DOI":"10.1002\/jmv.26182","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T14:23:56Z","timestamp":1592317436000},"page":"2874-2879","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A cross\u2010sectional community\u2010based observational study of asymptomatic SARS\u2010CoV\u20102 prevalence in the greater Indianapolis area"],"prefix":"10.1002","volume":"92","author":[{"given":"Kristin J.","family":"Meyers","sequence":"first","affiliation":[{"name":"Eli Lilly and Company Lilly Corporate Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Lilly Corporate Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris A.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Lilly UK, Windlesham  Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady T.","family":"Botros","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Lilly Corporate Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Knorr","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Lilly Corporate Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Manner","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Lilly Corporate Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Woodward","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Lilly Corporate Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"GhebreyesusT.General's opening remarks at the media briefing on COVID\u201019.https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020. Accessed 18 May 2020."},{"key":"e_1_2_8_3_1","unstructured":"COVID\u201019Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU).https:\/\/coronavirus.jhu.edu\/map.html. Accessed 18 May 2020."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2002125"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2565"},{"key":"e_1_2_8_6_1","article-title":"Suppression of COVID\u201019 outbreak in the municipality of Vo, Italy","author":"Lavezzo E","year":"2020","journal-title":"MedRxiv Preprint"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.10.2000180"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001468"},{"key":"e_1_2_8_9_1","unstructured":"Centers for Disease Control and Prevention.Influenza Specimen Collection.2014;https:\/\/www.cdc.gov\/flu\/pdf\/freeresources\/healthcare\/flu-specimen-collection-guide.pdf. Accessed 4 June 2020."},{"key":"e_1_2_8_10_1","unstructured":"Centers for Disease Control and Prevention.CDC 2019\u2010Novel Coronavirus (2019\u2010nCoV) Real\u2010Time PCR Diagnostic Panel.2020;https:\/\/www.fda.gov\/media\/134922\/download"},{"key":"e_1_2_8_11_1","unstructured":"Back on Track Indiana\u2010 Preliminary Results \u2010 May 13 2020. 2020;https:\/\/fsph.iupui.edu\/doc\/preliminary-results-random-sample-testing-may-13.pdf. Accessed 18 May 2020."},{"key":"e_1_2_8_12_1","unstructured":"United States Census Bureau.Quick Facts\u2014United States.2019;https:\/\/www.census.gov\/quickfacts\/fact\/table\/US\/PST045219"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.26182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.26182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T15:09:15Z","timestamp":1693840155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/jmv.26182"],"URL":"https:\/\/doi.org\/10.1002\/jmv.26182","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"2020-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}