{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:40:49Z","timestamp":1764603649465,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies reported that coronavirus disease 2019 (COVID\u201019) was likely to result in liver injury. However, few studies reported the impacts of COVID\u201019 on liver function in patients with chronic liver diseases. We aimed to describe a case series of COVID\u201019 patients with chronic hepatitis B virus (HBV) infection. Confirmed hospitalized COVID\u201019 patients from hospitals in 10 cities of Jiangsu province, China, were retrospectively included between 18 January 2020 and 26 February 2020. Demographic information, epidemiologic data, clinical features, and treatment data were extracted from medical records. Seven COVID\u201019 patients with chronic HBV infection were included. Six (85.7%) patients were male. The patients aged from 33 to 49 years. Two patients had HBV\u2010related cirrhosis. One patient (14.3%) was positive for serum HBV e\u2010antigen. On admission, 1 (14.3%) patient had mildly elevated alanine aminotransferase (ALT) level (&gt;40\u2009U\/L) and 1 (14.3%) had elevated aspartate aminotransferase (AST) level (&gt;40\u2009U\/L). The serum albumin level and platelet counts were decreased in two patients with HBV\u2010related liver cirrhosis. Three (42.9%) patients had elevated ALT level and 2 (28.6%) patients had elevated AST level in hospitalization. However, the peak ALT and AST level during hospitalization was 51\u2009U\/L and 44\u2009U\/L, respectively. As of 29 February 2020, all patients were discharged. No patient was admitted to the intensive care units or developed liver failure during hospitalization. The abnormalities of liver function are not uncommon on COVID\u201019 patients with chronic HBV infection in our case series. However, no patient developed severe liver\u2010related complications during hospitalization.<\/jats:p>","DOI":"10.1002\/jmv.26201","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T14:20:58Z","timestamp":1592576458000},"page":"2785-2791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A case series of COVID\u201019 patients with chronic hepatitis B virus infection"],"prefix":"10.1002","volume":"92","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Taizhou People's Hospital  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Medical University  Nanjing China"},{"name":"Department of Infectious Disease The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanwu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Infectious Diseases Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Infectious Diseases Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longgen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third People's Hospital of Changzhou  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianmin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third People's Hospital of Changzhou  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Quality Control Office Huai'an No. 4 People's Hospital  Huai'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine Huai'an No. 4 People's Hospital  Huai'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-010X","authenticated-orcid":false,"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Medical University  Nanjing China"},{"name":"Department of Infectious Disease The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization. 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