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Here, we explored the molecular prevalence of HAdVs by simultaneous sequencing of hexon and fiber. Then, the penton gene fragments of HAdV\u2010C species were determined by sequencing. Finally, genomic and proteotyping analysis were performed for exploration of molecular evolution of unique HAdV\u20106. Our results showed that dominant molecular types of HAdVs were HAdV\u20103, HAdV\u20102, and HAdV\u20101 based on the hexon and fiber genotype. Among H2F2 isolates, P1H2F2 was most common, followed by P2H2F2 and HAdV\u201089. The clinical symptoms of HAdV\u20101 or HAdV\u20102 infected patients were more severe than HAdV\u20103 infected patients, the prognosis of HAdV\u20101, HAdV\u20102, and HAdV\u20103 infected patients was indifference. Genomic and proteotyping analysis demonstrated that DT15 was different from HAdV\u20106 prototype, with high\u2010discrepant sequences localized in the E3 region. In conclusion, HAdV\u20101 and HAdV\u20102 have a high affinity to infect younger children and cause more severe symptoms than HAdV\u20103. The E3 gene of HAdV\u2010C species was considered as highly recombination and mutation region.<\/jats:p>","DOI":"10.1002\/jmv.26203","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T13:24:06Z","timestamp":1592832246000},"page":"3111-3118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular typing and genomic characteristic of human adenoviruses in Datong, Northern China"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-9775","authenticated-orcid":false,"given":"Tianxing","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"State Key Laboratories of Respiratory Diseases The First Affiliated Hospital of Guangzhou Medical University Guangzhou 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