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Hypoxic\/metabolic changes produced by intense inflammatory response against the virus triggers cytokine storm and subsequently acute respiratory distress syndrome and multiple organ failure. Hypoxic\/metabolic changes result in encephalopathy. The presence of comorbidities predisposes to hypoxic\/metabolic changes responsible for encephalopathy. Altered consciousness, ranging from mild confusion, delirium, to deep coma, is hallmark clinical features. Cortical and subcortical T2\/FLAIR signal changes are common neuroimaging abnormalities. In a few isolated case reports of SARS\u2010CoV\u20102 encephalitis, the virus has been demonstrated in cerebrospinal fluid. The presence of anosmia and ageusia can help in differentiation from other encephalopathies. We analyzed published reports on coronavirus disease 2019\u2010associated encephalopathy. Encephalopathy is common in older patients, the majority are more than 50 years of age. The patients having encephalopathy\/encephalitis are either severely or critically ill. Many patients were already on mechanical ventilation. Lung abnormalities are noted in almost all of the patients, presenting with encephalopathy. Encephalopathy is always preceded by commoner clinical features, like, fever, cough, dyspnoea, and headache. In majority, patients are already in the intensive care unit, when encephalopathy develops.<\/jats:p>","DOI":"10.1002\/jmv.26207","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T14:20:40Z","timestamp":1592576440000},"page":"206-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["Encephalopathy in patients with COVID\u201019: A review"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-7083","authenticated-orcid":false,"given":"Ravindra Kumar","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Neurology King George Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal Kumar","family":"Paliwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"e_1_2_19_2_1","unstructured":"World Health Organization. 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