{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:06:22Z","timestamp":1764079582149,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470206"],"award-info":[{"award-number":["81470206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigates the clinical and imaging characteristics of coronavirus disease 2019 (COVID\u201019) patients with false\u2010negative nucleic acids. Mild\u2010to\u2010moderate COVID\u201019 patients, including 19 cases of nucleic acid false\u2010negative patients and 31 cases of nucleic acid positive patients, were enrolled. Their epidemiological, clinical, and laboratory examination data and imaging characteristics were analyzed. Risk factors for false negatives were discussed. Compared with the nucleic acid positive group, the false\u2010negative group had less epidemiological exposure (52.6% vs 83.9%; <jats:italic>P<\/jats:italic>\u2009\u2009=\u2009.025), less chest discomfort (5.3% vs 32.3%; <jats:italic>P<\/jats:italic>\u2009\u2009=\u2009.035), and faster recovery (10 [8, 13] vs 15 [11, 18.5] days; <jats:italic>P<\/jats:italic>\u2009\u2009=\u2009.005). The number of involved lung lobes was (2 [1, 2.5] vs 3 [2, 4] days; <jats:italic>P<\/jats:italic>\u2009\u2009=\u2009.004), and the lung damage severity score was (3 [2.5, 4.5] vs 5 [4, 9] days; <jats:italic>P<\/jats:italic>\u2009\u2009=\u2009.007), which was lighter in the nucleic acid false\u2010negative group. Thus, the absence of epidemiological exposure may be a potential risk factor for false\u2010negative nucleic acids. The false\u2010negative cases of COVID\u201019 are worth noting because they have a risk of viral transmission without positive test results, lighter clinical manifestations, and less history of epidemiological exposure.<\/jats:p>","DOI":"10.1002\/jmv.26242","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T19:18:08Z","timestamp":1593544688000},"page":"448-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical characteristics and risk factors of mild\u2010to\u2010moderate COVID\u201019 patients with false\u2010negative SARS\u2010CoV\u20102 nucleic acid"],"prefix":"10.1002","volume":"93","author":[{"given":"Yan","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital, The First School of Clinical Medicine Southern Medical University  Nanjing China"},{"name":"Department of Respiratory and Critical 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Southern Medical University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Hospital Southern Medical University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shenzhen Hospital Southern Medical University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shenzhen Hospital Southern Medical University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shenzhen Hospital Southern Medical University  Shenzhen 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