{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:45:02Z","timestamp":1759938302871,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770681","81974086","81770684","81974087","81700597"],"award-info":[{"award-number":["81770681","81974086","81770684","81974087","81700597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the early stages of the pandemic, some coronavirus disease (COVID\u201019) patients were misdiagnosed as having influenza, which aroused the concern that some deaths attributed to influenza were actually COVID\u201019\u2010related. However, little is known about whether coinfection with influenza contributes to severity of COVID\u201019 pneumonia, and the optimal therapeutic strategy for these patients. We retrospectively studied 128 hospitalized patients with COVID\u201019 pneumonia. All patients were positive severe acute respiratory syndrome coronavirus 2 positive by nucleic acid detection. Sixty\u2010four cases were coinfected with influenza A\/B and the other 64 were influenza negative, matched by age, sex, and days from onset of symptoms. Among the 64 coinfected patients, 54 (84.4%) were coinfected with influenza A, and 10 (15.6%) with influenza B. The median duration of viral shedding time from admission was longer for patients with influenza coinfection (17.0 days) than for those without influenza coinfection (12.0 days) (<jats:italic>P\u2009<\/jats:italic>&lt;\u2009.001). The multivariable Cox proportional hazards model showed that the hazards ratio of resolution in lung involvement was 1.878 (<jats:italic>P<\/jats:italic>\u2009=\u2009.020) for patients administered lopinavir\/ritonavir, compared with those not administered lopinavir\/ritonavir (95% confidence interval: 1.103\u20103.196). Among influenza coinfected patients, those treated with lopinavir\/ritonavir exhibited faster pneumonia resolution within 2 weeks after symptom onset (37% vs 1%; <jats:italic>P<\/jats:italic>\u2009=\u2009.001). There was no difference in lung involvement between influenza coinfected and noninfected groups. Lopinavir\/ritonavir eliminated the difference of lung involvement between influenza coinfected and noninfected groups, indicating that lopinavir\/ritonavir is associated with pneumonia resolution in COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.26260","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T14:05:11Z","timestamp":1593871511000},"page":"472-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lopinavir\/ritonavir is associated with pneumonia resolution in COVID\u201019 patients with influenza coinfection: A retrospective matched\u2010pair cohort study"],"prefix":"10.1002","volume":"93","author":[{"given":"Chong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Healthy, School of Medicine and Health Management, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangchang","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-9755","authenticated-orcid":false,"given":"Rui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13383"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.8.2000170"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332417"},{"key":"e_1_2_13_12_1","unstructured":"National Health Commission of the People's Republic of China. Diagnosis and treatment protocols of pneumonia caused by a novel coronavirus (trial version 7). 2020.http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202003\/46c9294a7dfe4cef80dc7f5912eb1989\/files\/ce3e6945832a438eaae415350a8ce964.pdf"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200370"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012213432501"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405789"},{"key":"e_1_2_13_16_1","doi-asserted-by":"crossref","unstructured":"ZhouF YuT DuR et al.Clinical course and risk factors for mortality of adult inpatients with COVID\u201019 in Wuhan China: a retrospective cohort study.Lancet.2020.","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0588"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2606.200299"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","unstructured":"DingQ LuP FanY XiaY LiuM.The clinical characteristics of pneumonia patients co\u2010infected with 2019 novel coronavirus and influenza virus in Wuhan China.J Med Virol.2020.","DOI":"10.1002\/jmv.25781"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy115"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.21.17.1352.34419"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.03.025"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"issue":"6","key":"e_1_2_13_24_1","first-page":"3390","article-title":"Clinical efficacy of lopinavir\/ritonavir in the treatment of coronavirus disease 2019","volume":"24","author":"Ye XT","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01342-0"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2020.01030"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001737"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.26260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.26260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T09:54:31Z","timestamp":1693734871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jmv.26260"],"URL":"https:\/\/doi.org\/10.1002\/jmv.26260","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"2020-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}