{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:26Z","timestamp":1740104126858,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we aimed to highlight the common early\u2010stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID\u201019) pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In hospitalized patients, the acute phase disease duration was followed using the Brescia\u2010COVID respiratory severity scale. Noninvasive ventilation was administered based on clinical judgment. Patients requiring oropharyngeal intubation were excluded from the study. For parameters to be measured at the hospital entrance, age, clinical history, National Early Warning Score 2 (a multiparametric score system), partial pressure of oxygen in arterial blood\/fraction of inspired oxygen (P\/F ratio), C\u2010reactive protein, and blood cell count were selected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 64 patients, age (direct relationship), P\/F, and platelet number (inverse relationship) independently accounted for 43% of the acute phase duration of the disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the first time, the present results revealed that the acute phase duration of noncomplicated pneumonia, resulting from severe acute respiratory syndrome coronavirus 2, is independently predicted from a patient's age, as well as based on the hospital entrance values of P\/F ratio and peripheral blood platelet count.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26281","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T15:33:45Z","timestamp":1594308825000},"page":"513-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early\u2010stage predictors of the acute phase duration in uncomplicated COVID\u201019 pneumonia"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-3245","authenticated-orcid":false,"given":"Claudio","family":"Carallo","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Imperial College London, South Kensington Campus London UK"},{"name":"Department of Clinical and Experimental Medicine, Metabolic Diseases Unit Magna Gr\u00e6cia University Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Pugliese","sequence":"additional","affiliation":[{"name":"High\u2010Intensity Internal Medicine Unit Santa Maria del Carmine Hospital Rovereto Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5961-1741","authenticated-orcid":false,"given":"Cesare","family":"Tripolino","sequence":"additional","affiliation":[{"name":"Research in Advanced Neuro Rehabilitation, Istituto Sant'Anna Crotone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Lenzi","sequence":"additional","affiliation":[{"name":"High\u2010Intensity Internal Medicine Unit Santa Maria del Carmine Hospital Rovereto Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Oliveri","sequence":"additional","affiliation":[{"name":"High\u2010Intensity Internal Medicine Unit Santa Maria del Carmine Hospital Rovereto Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Fasani","sequence":"additional","affiliation":[{"name":"Internal Medicine plus Infectious Disease Units Santa Chiara Hospital  Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni M.","family":"Guarrera","sequence":"additional","affiliation":[{"name":"APSS PA Trento Trento Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Spagnolli","sequence":"additional","affiliation":[{"name":"Internal Medicine plus Infectious Disease Units Santa Chiara Hospital  Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Cozzio","sequence":"additional","affiliation":[{"name":"High\u2010Intensity Internal Medicine Unit Santa Maria del Carmine Hospital Rovereto Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019\u2010nCoV) infection is suspected. Interim guidance 13 March 2020.https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/clinical-management-of-novel-cov.pdf"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040941"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1328"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"QiX JiangZ YuQ et al. Machine learning\u2010based CT radiomics model for predicting hospital stay in patients with pneumonia associated with SARS\u2010CoV\u20102 infection: a multicenter study.medRxiv.2020.https:\/\/doi.org\/10.1101\/2020.02.29.20029603","DOI":"10.1101\/2020.02.29.20029603"},{"key":"e_1_2_9_6_1","unstructured":"Royal College of Physicians. National early warning score (NEWS) 2: standardizing the assessment of acute\u2010illness severity in the NHS. Updated report of a working party. 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