{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:25:39Z","timestamp":1783571139279,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Treatment options for severe acute respiratory syndrome\u2010related coronavirus\u20102 (SARS\u2010CoV\u20102) are limited with no clarity on efficacy and safety profiles. We performed a systematic review and meta\u2010analysis of studies on patients \u226518 years reporting data on therapeutic interventions in SARS\u2010CoV\u20102. Primary outcome was all\u2010cause mortality and secondary outcomes were rates of mechanical ventilation, viral clearance, adverse events, discharge, and progression to severe disease. Pooled rates and odds ratios (OR) were calculated. Twenty\u2010nine studies with 5207 patients were included. Pooled all\u2010cause mortality in intervention arm was 12.8% (95% confidence interval [CI]: 8.1%\u201017.4%). Mortality was significantly higher for studies using hydroxychloroquine (HCQ) for intervention (OR: 1.36; 95% CI: 0.97\u20101.89). Adverse events were also higher in HCQ subgroup (OR: 3.88; 95% CI: 1.60\u20109.45). There was no difference in other secondary outcomes. There is a need for well\u2010designed randomized clinical trials for further investigation of every therapeutic intervention for further insight into different therapeutic options.<\/jats:p>","DOI":"10.1002\/jmv.26302","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T10:59:01Z","timestamp":1594810741000},"page":"775-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Systematic review and meta\u2010analysis of effectiveness of treatment options against SARS\u2010CoV\u20102 infection"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-4113","authenticated-orcid":false,"given":"Viveksandeep","family":"Thoguluva Chandrasekar","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Kansas Medical Center Kansas City Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2541-2055","authenticated-orcid":false,"given":"Bhanuprasad","family":"Venkatesalu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ochsner Clinic Foundation New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Spadaccini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Humanitas University and Research Hospital Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Manteuffel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"536","article-title":"\u2010nCoV and naming it SARS\u2010CoV\u20102","volume":"5","author":"The species Severe acute respiratory syndrome\u2010related coronavirus: classifying","year":"2020","journal-title":"Nature microbiology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"GandhiRT LynchJB Del RioC.Mild or moderate COVID\u201019 [published online ahead of print April 24 2020].The N Engl J Med.https:\/\/doi.org\/10.1056\/NEJMcp2009249","DOI":"10.1056\/NEJMcp2009249"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_8_1","article-title":"Hydroxychloroquine in patients mainly with mild to moderate COVID\u201019: an open\u2010label, randomized, controlled trial","volume":"369","author":"Tang W","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","unstructured":"GautretP LagierJC ParolaP et al.Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID\u201019 patients with at least a six\u2010day follow up: a pilot observational study [published online ahead of print April 11 2020].Travel Med Infect Dis.34:101663.https:\/\/doi.org\/10.1016\/j.tmaid.2020.101663","DOI":"10.1016\/j.tmaid.2020.101663"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"GautretP LagierJC ParolaP et al.Hydroxychloroquine and azithromycin as a treatment of COVID\u201019: results of an open\u2010label non\u2010randomized clinical trial [published online ahead of print March 20 2020].Int J Antimicro Ag.105949.https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105949","DOI":"10.1016\/j.ijantimicag.2020.105949"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012410"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"MahevasM TranV\u2010T RoumierM et al. 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