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This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole\u2010exome sequencing, the frequency of exonic variants of the <jats:italic>ACE2, TMPRSS2<\/jats:italic>, and <jats:italic>Furin<\/jats:italic> genes was analyzed in relation to presence or absence of SARS\u2010CoV\u20102 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The <jats:italic>ACE2<\/jats:italic> gene showed a low level of polymorphism, and none variant was significantly associated with SARS\u2010CoV\u20102 infection. These variants have previously been detected in Italy. While <jats:italic>TMPRSS2<\/jats:italic> is highly polymorphic, the variants found do not coincide with those described in other studies, with the exception of rs75603675, which may be associated with SARS\u2010CoV\u20102 infection. The synonymous variants rs61735792 and rs61735794 showed a significant association with infection. Despite the limited number of patients with SARS\u2010CoV\u20102 infection, some variants, especially in <jats:italic>TMPRSS2<\/jats:italic>, may be associated with COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.26319","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T11:12:55Z","timestamp":1595329975000},"page":"863-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["<i>ACE2, TMPRSS2<\/i>, and Furin variants and SARS\u2010CoV\u20102 infection in Madrid, Spain"],"prefix":"10.1002","volume":"93","author":[{"given":"Laura","family":"Torre\u2010Fuentes","sequence":"first","affiliation":[{"name":"Department of Neurology, Instituto de Neurociencias IdISSC Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Mat\u00edas\u2010Guiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, 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