{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:41:44Z","timestamp":1768812104522,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008478","name":"Instituto Nacional del C\u00e1ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although the effectiveness of direct\u2010acting antivirals (DAAs) for the treatment of chronic hepatitis C virus (HCV) has been reported in real\u2010world settings, predictive factors of treatment failure are lacking. Therefore, we sought to explore the baseline predictors of treatment response to DAAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective multicenter cohort study from the Latin American Liver Research Educational and Awareness Network (LALREAN) including patients who received DAA\u00a0treatment from May 2016 to April 2019. A multivariate logistic regression model was conducted to identify variables associated with\u00a0unachieved sustained virological response (SVR), defined as treatment failure (odds ratios [OR] and 95% confidence intervals [CIs]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2167 patients (55.2% with cirrhosis) who initiated DAA\u00a0therapy, 89.4% completed a full\u2010course treatment (n\u2009=\u20091938). Median treatment duration was 12 weeks, and 50% received ribavirin. Definitive suspension due to intolerance or other causes was observed in only 1.0% cases (n\u2009=\u200920). Overall non\u2010SVR12 was 4.5% (95% CI, 3.5\u20105.7). There were no significant differences in treatment failure according to HCV genotypes and the degree of fibrosis. Independently associated variables with DAA\u00a0failure were liver function impairment according to the Child\u2010Pugh score B OR, 2.09 (<jats:italic>P<\/jats:italic>\u2009=\u2009.06), Child\u2010Pugh C OR, 11.7 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001); and liver transplant (LT) recipient OR, 3.75 (<jats:italic>P<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this real\u2010life setting, higher DAA\u00a0treatment failure rates were observed in patients with decompensated cirrhosis and in LT recipients. These predictive baseline factors should be addressed to individualize the appropriate time\u2010point of DAA\u00a0treatment (NCT03775798; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26383","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:01:01Z","timestamp":1596553261000},"page":"3545-3555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Decompensated cirrhosis and liver transplantation negatively impact in DAA treatment response: Real\u2010world experience from HCV\u2010LALREAN cohort"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-0683","authenticated-orcid":false,"given":"Ezequiel","family":"Ridruejo","sequence":"first","affiliation":[{"name":"Hepatology and Liver Transplant Unit Hospital Universitario Austral Pilar Argentina"},{"name":"Hepatology Section, Department of Medicine Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC) Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplant Unit Hospital Universitario Austral Pilar Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7026-9908","authenticated-orcid":false,"given":"Manuel","family":"Mendizabal","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplant Unit Hospital Universitario Austral Pilar Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Cheinquer","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Universidad de Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Herz","family":"Wolff","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Universidad de Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Anders","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Alem\u00e1n Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Reggiardo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Provincial del Centenario Rosario Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Ameigeiras","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Ramos Mej\u00eda Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Palazzo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Padilla Tucum\u00e1n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Alonso","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplant Unit Hospital Universitario Austral Pilar Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Schinoni","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Universidade Federal do Bahia Salvador do Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Grazia Videla","family":"Zuain","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hostpial Zubizarreta Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Tanno","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Provincial del Centenario Rosario Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e1n","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Arturo O\u00f1ativia Salta Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Santos","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Fundaci\u00f3n Cardioinfantil Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta","family":"Peralta","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Francisco J. Mu\u00f1iz Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Soza","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Vistarini","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Ramos Mej\u00eda Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Adrover","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital San Roque La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Brit\u00e1nico Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Perez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Padilla Tucum\u00e1n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelia","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital de Cl\u00ednicas Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Estepo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Cosme Argerich Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Bruno","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Cosme Argerich Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Descalzi","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplant Unit Fundaci\u00f3n Favaloro Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Sixto","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Jos\u00e9 Mar\u00eda Cullen Santa Fe Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Borzi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital Rossi La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cocozzella","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital San Roque La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Zerega","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplant Unit Sanatorio Allende C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division Hospital de Cl\u00ednicas de Porto Alegre de Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Var\u00f3n","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Francisco J. Mu\u00f1iz Ciudad de Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Silva","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplant Unit Hospital Universitario Austral Pilar Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Latin American Liver Research Educational and Awareness Network (LALREAN)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO Global hepatitis report;2017.http:\/\/apps.who.int\/iris\/bitstream\/10665\/255016\/1\/9789241565455-eng.pdf?ua=1. Accessed March 30 2020."},{"key":"e_1_2_10_3_1","unstructured":"PAHO and WHO OPS\/OMS alienta a los pa\u00edses de las Am\u00e9ricas a actuar para reducir muertes por hepatitis y mejorar prevenci\u00f3n y el tratamiento; 2017.http:\/\/www.paho.org\/hq\/index.php?option=com_content&view=article&id=12334%3Aopsoms-alienta-paises-americas-reducir-muertes-por-hepatitis&Itemid=1926&lang=es. Accessed March 30 2020."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_10_5_1","unstructured":"American Association for the Study of Liver Disease (AASLD).http:\/\/www.hcvguidelines.org\/full-report-view. Accessed March 30 2020."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13148"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24816"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25033"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2018.04.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2018.06.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.2717"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2019.08.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.771"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185728"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3061"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz214"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_10_20_1","unstructured":"National Institutes of Health and National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.03. Bethesda MD: National Institutes of Health;2010."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25552"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200568"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13162"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14478"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13218"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx158"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27922"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222605"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.04.017"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15598"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.044"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32111-1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.10.017"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101114"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215783"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2018.1535186"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14170"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.26383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.26383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:48:22Z","timestamp":1693226902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/jmv.26383"],"URL":"https:\/\/doi.org\/10.1002\/jmv.26383","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]},"assertion":[{"value":"2020-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}