{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:06:32Z","timestamp":1785006392137,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The full impact of coronavirus disease 2019 (COVID\u201019) on pregnancy remains uncharacterized. Current literature suggests minimal maternal, fetal, and neonatal morbidity and mortality. COVID\u201019 manifestations appear similar between pregnant and nonpregnant women. We present a case of placental severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) virus in a woman with mild COVID\u201019 disease, then review the literature. Reverse transcriptase polymerase chain reaction was performed to detect SARS\u2010CoV\u20102. Immunohistochemistry staining was performed with specific monoclonal antibodies to detect SARS\u2010CoV\u20102 antigen or to identify trophoblasts. A 29\u2010year\u2010old multigravida presented at 40\u20104\/7 weeks for labor induction. With myalgias 2 days prior, she tested positive for SARS\u2010CoV\u20102. We demonstrate maternal vascular malperfusion, with no fetal vascular malperfusion, as well as SARS\u2010CoV\u20102 virus in chorionic villi endothelial cells, and also rarely in trophoblasts. To our knowledge, this is the first report of placental SARS\u2010CoV\u20102 despite\n                    <jats:italic>mild<\/jats:italic>\n                    COVID\u201019 disease (no symptoms of COVID\u201019 aside from myalgias); patient had no fever, cough, or shortness of breath, but only myalgias and sick contacts. Despite her mild COVID\u201019 disease in pregnancy, we demonstrate placental vasculopathy and presence of SARS\u2010CoV\u20102 virus across the placenta. Evidence of placental COVID\u201019 raises concern for placental vasculopathy (potentially leading to fetal growth restriction and other pregnancy complications) and possible vertical transmission\u2014especially for pregnant women who may be exposed to COVID\u201019 in early pregnancy. This raises important questions of whether future pregnancy guidance should include stricter pandemic precautions, such as screening for a wider array of COVID\u201019 symptoms, increased antenatal surveillance, and possibly routine COVID\u201019 testing throughout pregnancy.\n                  <\/jats:p>","DOI":"10.1002\/jmv.26386","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T10:59:27Z","timestamp":1596538767000},"page":"1038-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Placental SARS\u2010CoV\u20102 in a pregnant woman with mild COVID\u201019 disease"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-9556","authenticated-orcid":false,"given":"Albert L.","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine and Fertility Center University of Missouri\u2010Columbia School of Medicine  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Guan","sequence":"additional","affiliation":[{"name":"MU Center for Research on Influenza Systems Biology (CRISB) University of Missouri  Columbia Missouri"},{"name":"Department of Molecular Microbiology and Immunology, School of Medicine University of Missouri  Columbia Missouri"},{"name":"Bond Life Sciences Center University of Missouri  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomical Sciences University of Missouri\u2010Columbia School of Medicine  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine University of Missouri\u2010Columbia School of Medicine  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Khaleel","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics University of Missouri\u2010Columbia School of Medicine  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Kagan","sequence":"additional","affiliation":[{"name":"University of Missouri School of Medicine  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanna C.","family":"Tuhlei","sequence":"additional","affiliation":[{"name":"University of Missouri School of Medicine  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Feng","family":"Wan","sequence":"additional","affiliation":[{"name":"MU Center for Research on Influenza Systems Biology (CRISB) University of Missouri  Columbia Missouri"},{"name":"Department of Molecular Microbiology and Immunology, School of Medicine University of Missouri  Columbia Missouri"},{"name":"Bond Life Sciences Center University of Missouri  Columbia Missouri"},{"name":"Department of Electrical Engineering and Computer Science, College of Engineering University of Missouri  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"COVID\u201019 cases in the US.https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/cases-updates\/cases-in-us.html. 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