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Of 432 studies found, only six studies fulfilled the inclusion criteria, which includes: clinical trials, age more than 12 years with nonsevere COVID\u201019, polymerase chain reaction\u2010confirmed COVID\u201019, hydroxychloroquine is the intervention beyond the usual care. Data extraction and bias risk assessment were done by two independent authors. Both fixed\u2010effect and random\u2010effect models were utilized for pooling data using risk difference as a summary measure. The primary outcomes are clinical and radiological COVID\u201019 progression, severe acute respiratory syndrome coronavirus\u20102 clearance in the pharyngeal swab, and mortality. The secondary outcomes are the adverse effects of hydroxychloroquine.<\/jats:p><jats:p>Among 609 COVID\u201019 confirmed patients obtained from pooling six studies, 294 patients received hydroxychloroquine and 315 patients served as a control. Hydroxychloroquine significantly prevents early radiological progression relative to control with risk difference and 95% confidence interval of \u22120.2 (\u22120.36 to \u22120.03). On the other hand, hydroxychloroquine did not prevent clinical COVID\u201019 progression, reduce 5\u2010day mortality, or enhance viral clearance on days 5, 6, and 7. Moreover, many adverse effects were reported with hydroxychloroquine therapy. Failure of hydroxychloroquine to show viral clearance or clinical benefits with additional adverse effects outweigh its protective effect from radiological progression in nonsevere COVID\u201019 patients. Benefit\u2010risk balance should determine the hydroxychloroquine use in COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.26442","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T06:31:49Z","timestamp":1598596309000},"page":"1265-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hydroxychloroquine for treatment of nonsevere COVID\u201019 patients: Systematic review and meta\u2010analysis of controlled clinical trials"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-9944","authenticated-orcid":false,"given":"Hozaifa Khalil","family":"Elsawah","sequence":"first","affiliation":[{"name":"Department of Biostatistics, High Institute of Public Health Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9832-5086","authenticated-orcid":false,"given":"Mohamed 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