{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:24:47Z","timestamp":1747149887951,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010805","name":"Forskningsr\u00e5det i Syd\u00f6stra Sverige","doi-asserted-by":"publisher","award":["FORSS\u2010663331"],"award-info":[{"award-number":["FORSS\u2010663331"]}],"id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Viral gastroenteritis is a major source of morbidity and mortality, predominantly caused by so\u2010called NOROAD viruses (norovirus, rotavirus, and adenovirus). In approximately onethird of all cases, however, the exact etiology is unknown. The in 2007 discovered human cardiovirus Saffold virus (SAFV) may prove to be a plausible candidate to explain this diagnostic gap. This virus, a member of the <jats:italic>Picornaviridae<\/jats:italic> family which is closely related to the murine viruses Theiler's murine encephalomyelitis virus and Theravirus, is a widespread pathogen and causes infection early in life. Screening of 238 fecal or vomitus samples obtained from NOROAD\u2010negative, elderly patients with acute gastroenteritis at the University Hospital of Link\u00f6ping showed that SAFV is present in low abundance (4.6%). Phylogenetic analysis of the VP1 gene revealed a Swedish isolate belonging to the highly common and in Europe widespread SAFV\u20103 genotype. This genotype is also related to previously reported Asian strains. This study describes the first molecular typing of a Swedish SAFV isolate and is the first report to document the circulation of SAFV among elderly people. The pathogenicity of SAFV is, as of yet, still under debate; further studies are necessary to determine its role in the development of disease.<\/jats:p>","DOI":"10.1002\/jmv.26452","type":"journal-article","created":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T14:13:18Z","timestamp":1598105598000},"page":"3980-3984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Saffold virus infection in elderly people with acute gastroenteritis in Sweden"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-3944","authenticated-orcid":false,"given":"Helena","family":"Vandesande","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biomedical Sciences Faculty of Health and Life Sciences Linnaeus University Kalmar Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Edman","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomedical Sciences Faculty of Health and Life Sciences Linnaeus University Kalmar Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Rondahl","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Clinical and Experimental Medicine Link\u00f6ping\u00a0University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Falkeborn","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Clinical and Experimental Medicine Link\u00f6ping\u00a0University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Serrander","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Clinical and Experimental Medicine Link\u00f6ping\u00a0University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-4826","authenticated-orcid":false,"given":"A. 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