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This review elucidated that LUVs could be highly safe with selective use of neutralizing antivirus antibodies, natural antiglycan antibodies, nonantibody antivirals, and ectopic inoculation. Also, LUVs could be of high efficacy, high development speed, and high production efficiency, with the development of humanized monoclonal antibodies and other modern technologies. They could circumvent antibody\u2010dependent enhancement and maternal\u2010derived antibody interference. With these important advantages, LUVs could be more powerful than other vaccines for controlling some viral diseases, and they warrant urgent investigation with animal experiments and clinical trials for defeating the COVID\u201019 pandemic caused by the novel coronavirus SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1002\/jmv.26453","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T23:38:18Z","timestamp":1598312298000},"page":"1943-1949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Live unattenuated vaccines for controlling viral diseases, including COVID\u201019"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-0830","authenticated-orcid":false,"given":"Ji\u2010Ming","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Science and Engineering Foshan University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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