{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:47:04Z","timestamp":1793018824239,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Norovirus\u2010like particle (VLP) vaccine is promising against human norovirus infection. Unfortunately, genetic diversity of norovirus hindered the development of this vaccine. In this study, the immunogenicity of norovirus VLPs induced by the endemic GII.4 and the epidemic GII.17 genotypes, and the cross\u2010reactivity between them as well as GI.1 and GII.3 VLPs were evaluated in mice by using serum IgG and histo\u2010blood group antigen (HBGA) blocking antibodies as index. Results showed well immunogenicity of both GII.4 and GII.17 VLPs in mice. Serum IgG GMT (Geometric Mean Titer) were 3.63 (GII.4) and 3.88 (GII.17) respectively, and sustained to the 15th week. The HBGA blocking antibodies were 130 (GII.4) and 360 (GII.17) respectively at the end of the 4th week. Additionally, there was a dramatically statistical difference found in the cross\u2010reactivity within genogroup (GII.3, GII.4 and GII.17) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and also showed similar difference between genogroups (GI.1 vs. GII.3, GII.4 and GII.17) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Summarized the pPICZa <jats:italic>pichi pichia<\/jats:italic> expression system showed a potential to be the alternative for expression of norovirus VLPs in secretion form, and the little cross\u2010reactivity found between the endemic strain and the epidemic strain provides an evident for the consideration of selecting candidates of norovirus vaccine strains.<\/jats:p>","DOI":"10.1002\/jmv.26474","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T19:47:16Z","timestamp":1598989636000},"page":"3974-3979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The endemic GII.4 norovirus\u2010like\u2010particle induced\u2010antibody lacks of cross\u2010reactivity against the epidemic GII.17 strain"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-5521","authenticated-orcid":false,"given":"Jialiang","family":"Du","sequence":"first","affiliation":[{"name":"Division of Enteric Viral Vaccines National Institutes for Food and Drug Control Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Gu","sequence":"additional","affiliation":[{"name":"Division of Enteric Viral Vaccines National Institutes for Food and Drug Control Beijing China"},{"name":"National Vaccine and Serum Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Enteric Viral Vaccines National Institutes for Food and Drug Control Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiming","family":"Li","sequence":"additional","affiliation":[{"name":"National Vaccine and Serum Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Enteric Viral Vaccines National Institutes for Food and Drug Control Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Enteric Viral Vaccines National Institutes for Food and Drug Control Beijing 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