{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:37:35Z","timestamp":1762868255305,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Asymptomatic and convalescent coronavirus disease 2019 (COVID\u201019) subjects may carry severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) for months in their upper respiratory ways. Desiring to permanently clean the mucosal surfaces, we investigated the chemical agents that fit to rapidly degrade the virus. Among these, hydrogen peroxide, initially tested by two of us for tolerability, showed both good performance and acceptable side effects (burning sensation for 15\u201320\u2009s). We contacted circles of family physicians and the ATS Milano (Territorial Assistance and Prevention Service), and we tested this procedure on eight persistent carriers of SARS\u2010CoV\u20102, performing swabs before the procedure and after it until the reappearance of the virus or until 14 days (the incubation period), keeping the surfaces clean with a hypertonic solution. Our patients had a median time from exposure or symptom onset of 111 days, and three had relapsed after being declared \u201ccured\u201d\u00a0(two consecutive negative swabs after quarantine). One patient had a baseline negative swab and was excluded, and two successfully ended the 14 days' course, four suppressed viral elimination for 72\u2009h,\u00a0and one for 48\u2009h, all rebounding to weak positive (cycle thresholds above 24). Although temporarily effective, such measures may have some place in the control of viral shedding\u00a0to protect the most fragile subjects.<\/jats:p>","DOI":"10.1002\/jmv.26485","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:52:10Z","timestamp":1599144730000},"page":"1766-1769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Short\u2010term inhibition of SARS\u2010CoV\u20102 by hydrogen peroxide in persistent nasopharyngeal carriers"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-1035","authenticated-orcid":false,"given":"Amedeo F.","family":"Capetti","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Borgonovo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Morena","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Lupo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Cossu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Passerini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Dedivitiis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Rizzardini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases \u201cLuigi Sacco\u201d University Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2009758"},{"journal-title":"Clin Infect Dis","article-title":"Antibody responses to SARS\u2010CoV\u20102 in patients of novel coronavirus disease 2019 [published online ahead of print March 28, 2020]","author":"Zhao J","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.201595"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106026"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17155313"},{"key":"e_1_2_7_7_1","unstructured":"Interim Guidance. Centers for disease control and prevention discontinuation of transmission\u2010based precautions and disposition of patients with COVID\u201019 in healthcare settings.\u00a0https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/disposition-hospitalized-patients.html. Accessed 29 July\u00a02020."},{"key":"e_1_2_7_8_1","unstructured":"WHO: Criteria for releasing COVID\u201019 patients from isolation.\u00a0https:\/\/www.who.int\/news-room\/commentaries\/detail\/criteria-for-releasing-covid-19-patients-from-isolation. Accessed 29 July\u00a02020."},{"key":"e_1_2_7_9_1","unstructured":"Protocol G1.2020.0010603 06\/03\/2020. Indirizzi in merito all'isolamento domiciliare.https:\/\/www.ats-milano.it\/portale\/Portals\/0\/emergenza%20coronavirus\/Farmacia\/nota%20ulteriore%20proorga%20PT%20AIFA%20fino%20al%2031%20agosto.pdf. Accessed 29 July\u00a02020."},{"key":"e_1_2_7_10_1","unstructured":"Decontamination and Reuse of Filtering Facepiece Respirators.\u00a0https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/ppe-strategy\/decontamination-reuse-respirators.html. Accessed 29 July\u00a02020."},{"key":"e_1_2_7_11_1","unstructured":"Gruppo di lavoro ISS Biocidi COVID\u201019: Raccomandazioni ad interim sui disinfettanti nell'attuale emergenza COVID\u201019: presidi medico chirurgici e biocidi.https:\/\/www.epicentro.iss.it\/coronavirus\/pdf\/rapporto-covid-19-19-2020.pdfRapporto ISS COVID\u201019. \u00a0no. 19\/2020. Accessed 29 July\u00a02020."},{"key":"e_1_2_7_12_1","unstructured":"Medical Management Guidelines for Hydrogen Peroxide.www.atsdr.cdc.gov\/MMG\/MMG.asp?id=304%26tid=55#. 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