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In this study, we investigated the changes of liver stiffness by magnetic resonance elastogaraphy (MRE) during DAA therapy. A total of 308 patients were enrolled in the study. Liver stiffness was measured twice before and after DAA treatment using MRE and time\u2010course change of liver stiffness was investigated. The median (interquartile range) values for liver stiffness were 4.2 (3.2\u20136.1) kPa at baseline and 3.3 (2.6\u20134.8) kPa at SVR, demonstrating a significant improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). A total of 44% of patients had no improvement in liver stiffness despite achieving SVR. In patients with advanced fibrosis (lower level of albumin [Alb] or histological fibrosis stage F4), it was difficult to improve liver stiffness. Except for Alb, there were no blood tests associated with nonimprovement in liver stiffness, making these cases difficult to predict. In conclusion, despite obtaining SVR, improvement in liver stiffness could not be obtained in some cases, especially in patients with advanced fibrosis. In these patients, liver stiffness must be followed even if SVR is obtained.<\/jats:p>","DOI":"10.1002\/jmv.26490","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T16:05:11Z","timestamp":1599321911000},"page":"3744-3751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Changes of liver stiffness measured by magnetic resonance elastography during direct\u2010acting antivirals treatment in patients with chronic hepatitis C"],"prefix":"10.1002","volume":"93","author":[{"given":"Mayu","family":"Higuchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan"},{"name":"First Department of Internal Medicine, Faculty of Medicine University of Yamanashi Yamanashi 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