{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:02Z","timestamp":1740104162045,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pediatric cases of the coronavirus disease 2019 (COVID\u201019) are generally mild or asymptomatic, and are usually detected by virological examination following close contact with COVID\u201019 patients, often the children's parents. The detailed clinical features and virological data of pediatric patients with COVID\u201019, particularly young infants, remain unclear. Here, the clinical and virological characteristics of four children with COVID\u201019 including two young infants were investigated. One\u2010 and 4\u2010month\u2010old boys with COVID\u201019 were both asymptomatic, and seroconversion was demonstrated. These findings suggest that even young infants can mount an immune response against severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), despite having weaker immune defenses than adolescents and adults. Three\u2010year\u2010old boy, who was SARS\u2010CoV\u20102\u2010negative, was admitted to the same room as his SARS\u2010CoV\u20102\u2010positive father due to the lack of caregivers. Although he was asymptomatic, he had seroconverted to SARS\u2010CoV\u20102. Eleven\u2010year\u2010old boy, who was sibling of the 3\u2010year\u2010old boy, was also SARS\u2010CoV\u20102\u2010negative. He was isolated in his own room and did not seroconvert. If young children are SARS\u2010CoV\u20102 negative, they should be isolated from their SARS\u2010CoV\u20102\u2010positive parents. This may be difficult in practice, if parents with COVID\u201019 are the only available caregivers. In such situations, the most appropriate measures should be taken for each patient.<\/jats:p>","DOI":"10.1002\/jmv.26493","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T11:46:24Z","timestamp":1601034384000},"page":"1776-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune response against SARS\u2010CoV\u20102 in pediatric patients including young infants"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-7098","authenticated-orcid":false,"given":"Yoshiki","family":"Kawamura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Higashimoto","sequence":"additional","affiliation":[{"name":"Faculty of Medical Technology Fujita Health University School of Health Sciences  Toyoake 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Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kozawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-7682","authenticated-orcid":false,"given":"Tetsushi","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine  Toyoake 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