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Viral genome mutations exist commonly which may impact the encoded proteins, possibly resulting to varied effectivity of detection tools and disease treatment. Thus, this study surveyed the SARS\u2010CoV\u20102 genome and proteome and evaluated its mutation characteristics. Phylogenetic analyses of SARS\u2010CoV\u20102 genes and proteins show three major clades and one minor clade (P6810S; ORF1ab). The overall frequency and densities of mutations in the genes and proteins of SARS\u2010CoV\u20102 were observed. Nucleocapsid exhibited the highest mutation density among the structural proteins while the spike D614G was the most common, occurring mostly in genomes outside China and United States. ORF8 protein had the highest mutation density across all geographical areas. Moreover, mutation hotspots neighboring and at the catalytic site of RNA\u2010dependent RNA polymerase were found that might challenge the binding and effectivity of remdesivir. Mutation coldspots may present as conserved diagnostic and therapeutic targets were found in ORF7b, ORF9b, and ORF14. These findings suggest that the virion's genotype and phenotype in a specific population should be considered in developing diagnostic tools and treatment options.<\/jats:p>","DOI":"10.1002\/jmv.26548","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T18:34:16Z","timestamp":1600972456000},"page":"1702-1721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Genomic and proteomic mutation landscapes of SARS\u2010CoV\u20102"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-1322","authenticated-orcid":false,"given":"Christian Luke D. 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