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It is reported that SARS\u2010CoV\u20102 seems to have relatively low pathogenicity and higher transmissibility than previously outbroke SARS\u2010CoV. To explore the reason of the increased transmissibility of SARS\u2010CoV\u20102 compared with SARS\u2010CoV, we have performed a comparative analysis on the structural proteins (spike, envelope, membrane, and nucleoprotein) of two viruses. Our analysis revealed that extensive substitutions of hydrophobic to polar and charged amino acids in spike glycoproteins of SARS\u2010CoV2 creates an intrinsically disordered region (IDR) at the beginning of membrane\u2010fusion subunit and intrinsically disordered residues in fusion peptide. IDR provides a potential site for proteolysis by furin and enriched disordered residues facilitate prompt fusion of the SARS\u2010CoV2 with host membrane by recruiting molecular recognition features. Here, we have hypothesized that mutation\u2010driven accumulation of intrinsically disordered residues in spike glycoproteins play dual role in enhancing viral transmissibility than previous SARS\u2010coronavirus. These analyses may help in epidemic surveillance and preventive measures against COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.26598","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:27:01Z","timestamp":1602700021000},"page":"2790-2798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mutations in membrane\u2010fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID\u201019"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-508X","authenticated-orcid":false,"given":"Soumita","family":"Podder","sequence":"first","affiliation":[{"name":"Department of Microbiology Raiganj University Uttar Dinajpur West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avishek","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Microbiology Maulana Azad College Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapash","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Microbiology Raiganj University Uttar Dinajpur West Bengal India"},{"name":"Department of Bioinformatics Bose Institute Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.05.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2015.06.003"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization WHO. 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