{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:55Z","timestamp":1786978195242,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Crimean\u2013Congo hemorrhagic fever (CCHF), whose causative agent is CCHF\n                    <jats:italic>orthonairovirus<\/jats:italic>\n                    (CCHFV), demonstrates different symptoms in patients. Long noncoding RNAs (lncRNAs) take part in various pathological processes of viral diseases. They are prominent regulators of antiviral immune responses. To our knowledge, this study is the first study to investigate nuclear paraspeckle assembly transcript 1 (NEAT1), interferon (IFN) gamma antisense RNA 1 (IFNG\u2010AS1), and negative regulator of IFN response (NRIR) expression in CCHF in the literature. We selected these lncRNAs because they are related to IFN signal or IFN\u2010stimulated\u00a0genes. We investigated NEAT1, IFNG\u2010AS1, and NRIR gene expression in patients with CCHF. Total RNA was extracted from blood samples of 100 volunteers and NEAT1, IFNG\u2010AS1, and NRIR expression were measured using a quantitative real\u2010time polymerase chain reaction. NRIR expression was statistically significant in cases versus controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), fatals versus controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), and fatals versus nonfatals (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.01). Furthermore, NRIR was found statistically significant at some clinical parameters including alanine aminotransferase (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.03), international normalized ratio (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    =\u2009.03), prothrombin time\u00a0(\n                    <jats:italic>p<\/jats:italic>\n                    = .02), and active partial thromboplastin time (\n                    <jats:italic>p<\/jats:italic>\n                    = .01) in CCHF cases. NEAT1 and IFNG\u2010AS1 expression were downregulated in the case and fatal groups which were compared with controls. Our results demonstrate that NRIR may be important in CCHF pathogenesis and the target of CCHF treatment.\n                  <\/jats:p>","DOI":"10.1002\/jmv.26606","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T12:41:56Z","timestamp":1602852116000},"page":"3300-3304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of NEAT1, IFNG\u2010AS1, and NRIR expression in Crimean\u2013Congo hemorrhagic fever"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-457X","authenticated-orcid":false,"given":"Burcu","family":"Bayyurt","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-8793","authenticated-orcid":false,"given":"Aynur","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"Oksuz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3921-8061","authenticated-orcid":false,"given":"Serdal","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Sivas Cumhuriyet University Sivas 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