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Recently, a cluster of studies appeared, which presented empirical evidence for SARS\u2010CoV\u20102\u2010specific virulence factors that can explain key elements of COVID\u201019 pathology. These studies unravel multiple structural and nonstructural specifics of SARS\u2010CoV\u20102, such as\u00a0a unique FURIN cleavage site, papain\u2010like protease (SCoV2\u2010PLpro), ORF3b and nonstructural proteins, and dynamic conformational changes in the structure of spike protein during host cell fusion, which give it an edge in infectivity and virulence over previous coronaviruses causing pandemics. Investigators provided robust evidence that SARS\u2010CoV\u20102\u2010specific virulence factors may have an impact on viral infectivity and transmissibility\u00a0and disease severity as well as the development of immunity against the infection, including response to the vaccines. In this article, we are presenting a summarized account of the newly reported studies.<\/jats:p>","DOI":"10.1002\/jmv.26615","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T12:43:46Z","timestamp":1603284226000},"page":"1343-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["SARS\u2010CoV\u20102\u2010specific virulence factors in COVID\u201019"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-9568","authenticated-orcid":false,"given":"Ashutosh","family":"Kumar","sequence":"first","affiliation":[{"name":"Etiologically Elusive Disorders Research Network (EEDRN)  New Delhi India"},{"name":"Department of Anatomy All India Institute of Medical Sciences (AIIMS)  Patna 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