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Previous studies showed RAAS inhibitors increase the expression of ACE2, a cellular receptor for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), which provokes a concern that the use of ACEI and ARB in hypertensive individuals might lead to increased mortality and severity of coronavirus disease 2019 (COVID\u201019). To further investigate the effects of ACEI\/ARB on COVID\u201019 patients, we systematically reviewed relevant studies that met predetermined inclusion criteria in search of PubMed, Embase, Cochrane Library databases, medRxiv, and bioRxiv. The search strategy included clinical data published through October 12, 2020. Twenty\u2010six studies involving 8104 hypertensive patients in ACEI\/ARB\u2010treated group and 8203 hypertensive patients in non\u2010ACEI\/ARB\u2010treated group were analyzed. Random\u2010effects meta\u2010analysis showed ACEI\/ARB treatment was significantly associated with a lower risk of mortality in hypertensive COVID\u201019 patients (odds ratio [OR]\u2009=\u20090.624, 95% confidence interval [CI]\u2009=\u20090.457\u20130.852, <jats:italic>p<\/jats:italic>\u2009=\u2009.003, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200974.3%). Meta\u2010regression analysis showed that age, gender, study site, Newcastle\u2013Ottawa Scale scores, comorbidities of diabetes, coronary artery disease, chronic kidney disease, or cancer has no significant modulating effect of ACEI\/ARB treatment on the mortality of hypertensive COVID\u201019 patients (all <jats:italic>p<\/jats:italic>\u2009&gt;\u2009.1). In addition, the ACEI\/ARB treatment was associated with a lower risk of ventilatory support (OR\u2009=\u20090.682, 95% CI\u2009=\u20090.475\u20131.978, <jats:italic>p<\/jats:italic>\u2009=\u2009.037, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%). In conclusion, these results suggest that ACEI\/ARB medications should not be discontinued for hypertensive patients in the context of COVID\u201019 pandemic.<\/jats:p>","DOI":"10.1002\/jmv.26625","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T17:06:21Z","timestamp":1603472781000},"page":"1370-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["The use of renin\u2013angiotensin\u2013aldosterone system (RAAS) inhibitors is associated with a lower risk of mortality in hypertensive COVID\u201019 patients: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"93","author":[{"given":"Yixuan","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Human Virology and Oncology, Shantou University Medical College Shantou Guangdong Province 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