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Although the world is still in the stage of COVID\u201019 pandemic, the treatment of new cases and critically ill patients is the focus of the current work. However, COVID\u201019 patients lead to pulmonary fibrosis, such a serious threat to the prognosis of complications were also worthy of our attention. First of all, we proposed the possible mechanism of pulmonary fibrosis caused by SARS\u2010CoV\u20102, based on the published data of COVID\u201019 ((i) Direct evidence: pulmonary fibrosis was found in autopsy and pulmonary puncture pathology.\u00a0(ii) Indirect evidence: increased levels of fibrosis\u2010related cytokines[transforming growth factor [TGF]\u2010 \u03b2, tumor necrosis factor [TNF]\u2010 \u03b1, interleukin [IL]\u20106, etc] in peripheral blood of severe patients.) What is more, we summarized the role of three fibrosis\u2010related signaling pathways (TGF\u2010 \u03b2 signal pathway, WNT signal pathway and YAP\/TAZ signal pathway) in pulmonary fibrosis. Finally, we suggested the therapeutic value of two drugs (pirfenidone and nintedanib) for idiopathic pulmonary fibrosis in COVID\u201019\u2010induced pulmonary fibrosis.<\/jats:p>","DOI":"10.1002\/jmv.26634","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T09:43:21Z","timestamp":1603791801000},"page":"1378-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Discharge may not be the end of treatment: Pay attention to pulmonary fibrosis caused by severe COVID\u201019"],"prefix":"10.1002","volume":"93","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3625","authenticated-orcid":false,"given":"Zhao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanna","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"},{"name":"Department of Infectious Disease Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-7974","authenticated-orcid":false,"given":"Gui\u2010Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,\u00a0Center for Liver Disease Peking University First Hospital  Beijing China"},{"name":"Department of Infectious Disease Peking University International Hospital  Beijing China"},{"name":"The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"http:\/\/2019ncovchinacdccn\/2019-nCoV\/global.html. 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