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The aim of this study was to evaluate the role of mid\u2010regional proadrenomedullin (MR\u2010proADM) as a marker of SARS\u2010CoV2 related widespread endothelial damage, clinically identified by organs damage, disease severity and mortality. Patients with SARS\u2010CoV\u20102 infection has been prospectively enrolled and demographic characteristic, clinical and laboratory data has been evaluated. In the overall population, 58% developed acute respiratory distress syndrome (ARDS), 23.3% of patients died, 6.5% acute cardiac injury, 1.4% of patients developed acute ischemic stroke, 21.2% acute kidney injury, 11.8% acute liver damage, and 5.4% septic shock. The best MR\u2010proADM cut\u2010off values for ARDS development and mortality prediction were 3.04 and 2\u2009nmol\/L, respectively. Patients presenting with MR\u2010proADM values\u00a0\u22652\u2009nmol\/L showed a significantly higher mortality risk. In conclusion, MR\u2010proADM values\u00a0\u22652\u2009nmol\/L identify those patients with high mortality risk related to a multiorgan dysfunction syndrome. These patients must be carefully evaluated and considered for an intensive therapeutic approach.<\/jats:p>","DOI":"10.1002\/jmv.26676","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T12:54:59Z","timestamp":1605617699000},"page":"2820-2827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["High value of mid\u2010regional proadrenomedullin in COVID\u201019: A marker of widespread endothelial damage, disease severity, and mortality"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-4997","authenticated-orcid":false,"given":"Silvia","family":"Spoto","sequence":"first","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice E.","family":"Agr\u00f2","sequence":"additional","affiliation":[{"name":"Intensive Care and Pain Management, Department of Anesthesia University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sambuco","sequence":"additional","affiliation":[{"name":"Emergency Department University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Emergency Department University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Valeriani","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fogolari","sequence":"additional","affiliation":[{"name":"Unit of Clinical Laboratory Science University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Mangiacapra","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Science University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Costantino","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Medicine Department University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-9239","authenticated-orcid":false,"given":"Massimo","family":"Ciccozzi","sequence":"additional","affiliation":[{"name":"Unit of Medical Statistics and Molecular Epidemiology University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-8732","authenticated-orcid":false,"given":"Silvia","family":"Angeletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25688"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03022-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"World Health Organization. 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