{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:36Z","timestamp":1786977996245,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The infection of enterovirus 71 (EV71) resulted in hand, foot, and mouth disease and may lead to severe nervous system damage and even fatalities. There are no effective drugs to treat the EV71 virus and it is crucial to find novel drugs against it. Polysaccharide isolated from\n                    <jats:italic>Durvillaea antarctica<\/jats:italic>\n                    green algae has an antiviral effect. In this study,\n                    <jats:italic>D. antarctica<\/jats:italic>\n                    polysaccharide (DAPP) inhibited the infection of EV71 was demonstrated by 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT), reverse transcription polymerase chain reaction, flow cytometry, and western blot. MTT assay showed that DAPP had no toxicity on Vero cells at the concentration 250\u2009\u03bcg\/ml. Furthermore, DAPP significantly reduced the RNA level of EV71 in a dose\u2010dependent manner. Moreover, DAPP inhibited the Vero cells apoptosis induced by EV71 via the P53 signaling pathway. Meanwhile, the expression of signal transducer and activator of transcription 1 and mammalian target of rapamycin were increased and the proinflammatory cytokines were significantly inhibited by DAPP. Taken together, these results suggested that DAPP could be a potential pharmaceutical against the infection of EV71 virus.\n                  <\/jats:p>","DOI":"10.1002\/jmv.26693","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T07:40:48Z","timestamp":1606203648000},"page":"3532-3538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The inhibition of enterovirus 71 induced apoptosis by\n                    <i>Durvillaea antarctica<\/i>\n                    through P53 and STAT1 signaling pathway"],"prefix":"10.1002","volume":"93","author":[{"given":"Tiantian","family":"Xu","sequence":"first","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Li","sequence":"additional","affiliation":[{"name":"Center Laboratory, 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