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This study aims to investigate genotype diversity and molecular epidemiology of norovirus in Bangladesh. A total of 466 fecal specimens were collected from January 2014 to January 2019 from children below 5 years old with AGE in Bangladesh. All samples were analyzed by reverse transcriptase polymerase chain reaction to detect norovirus, and sequence analysis was conducted if found positive. Norovirus was detected in 5.1% (24 of 466) fecal specimens. Norovirus genotype GII.7 was predominant (62.5%, 15 of 24), followed by GII.3 (37.5%, 9 of 24). Coinfection between rotavirus and norovirus was found in 7 of 24 positive cases. Diarrhea (93.7%) and dehydration (89%) were the most common symptoms in children with AGE. About 80% of the positive cases were detected in children aged under 24 months. One seasonal peak (87.5% infection) was detected in the winter. This study suggests that norovirus continues to be one of the major etiologies of children AGE in Bangladesh. This study will provide a guideline to assess the burden of norovirus infection in Bangladesh, which will assist to combat against AGE.<\/jats:p>","DOI":"10.1002\/jmv.26772","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T12:23:15Z","timestamp":1609590195000},"page":"3564-3571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Molecular epidemiology and genetic diversity of norovirus infection in children with acute gastroenteritis in Bangladesh, 2014\u20132019"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-5673","authenticated-orcid":false,"given":"Shuvra Kanti","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Microbiology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-9726","authenticated-orcid":false,"given":"Nadim","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baki","family":"Billah","sequence":"additional","affiliation":[{"name":"Department of Zoology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanjir Tarek Ibn","family":"Siddique","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarequl","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anowar Khasru","family":"Parvez","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Azam","family":"Talukder","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung","family":"Phan","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology and Microbiology Nihon University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2017.03.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.07.036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.02.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31128-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002637"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.48"},{"key":"e_1_2_8_8_1","first-page":"s2209","article-title":"The molecular epidemiology of norovirus outbreaks in Victoria, 2016","volume":"42","author":"Bruggink LD","year":"2018","journal-title":"Commun Dis Intell"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017269"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-018-0233-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200911"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25684"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/B978-0-12-802241-2.00016-X","volume-title":"Structural Biology of Noroviruses. 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