{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:43:46Z","timestamp":1761129826607,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Various new clinical signs and symptoms, such as dysfunction of smell (anosmia) and taste (dysgeusia) have emerged ever since the coronavirus disease 2019 (COVID\u201019) pandemic begun. The objective of this study was to identify the clinical presentation and factors associated with 'new loss\/change of smell (anosmia) or taste (dysgeusia)' at admission in patients positive by real time polymerase chain reaction for SARS\u2010CoV\u20102 infection. All adult COVID\u201019 patients with new onset anosmia or dysgeusia at admission were included in study group. Equal number of age and gender matched COVID\u201019 patients without anosmia or dysgeusia at admission were included in the control group. A total of 261 COVID\u201019 patients were admitted during the study period of which 55 (21%) had anosmia and or dysgeusia. The mean (<jats:italic>SD<\/jats:italic>) age was 36 (13) years and majority were males (58%, <jats:italic>n<\/jats:italic>\u2009=\u200932). Comorbidity was present in 38% of cases (<jats:italic>n<\/jats:italic>\u2009=\u200921). Anosmia and dysgeusia were noted in more than 1\/5th of the cases. Anosmia (96%, <jats:italic>n<\/jats:italic>\u2009=\u200953) was more common than dysgeusia (75%, <jats:italic>n<\/jats:italic>\u2009=\u200941). Presence of both ansomia and dysgeusia was noted in 71% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200939). On comparing the cases with the controls, on univariate analysis, fever (higher in cases), rhinitis (lower in cases), thrombocytopenia, elevated creatinine and bilirubin (all higher in cases) were significantly associated with anosmia or dysgeusia. On multivariate analysis, only rhinitis (odds ratio [OR]:\u00a00.28; 95% confidence interval [CI]: 0.09\u20130.83; <jats:italic>p<\/jats:italic>\u2009=\u2009.02) thrombocytopenia (OR: 0.99; 95% CI: 0.99\u20130.99; <jats:italic>p<\/jats:italic>\u2009=\u2009.01) and elevated creatinine (OR: 7.6; 95% CI: 1.5\u201337.6; <jats:italic>p<\/jats:italic>\u2009= .01) remained significant. In this retrospective study of COVID\u201019 patients, we found anosmia and dysgeusia in more than 1\/5th of the cases. Absence of rhinitis, low platelet counts and elevated creatinine were associated with anosmia or dysgeusia in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26784","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T16:04:35Z","timestamp":1610553875000},"page":"2499-2504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["COVID\u201019 with and without anosmia or dysgeusia: A case\u2010control study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2486-6725","authenticated-orcid":false,"given":"Nishanth","family":"Dev","sequence":"first","affiliation":[{"name":"Department of Medicine VMMC &amp; Safdarjung Hospital Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-6550","authenticated-orcid":false,"given":"Jhuma","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and critical care VMMC &amp; Safdarjung Hospital Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh Chand","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Medicine VMMC &amp; Safdarjung Hospital Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charanjit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine VMMC &amp; Safdarjung Hospital Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine VMMC &amp; Safdarjung Hospital Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and critical care VMMC &amp; Safdarjung Hospital Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa330"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1"},{"key":"e_1_2_9_4_1","unstructured":"BrannDH TsukaharaT WeinrebC et al. Non\u2010neuronal expression of SARS\u2010CoV\u20102 entry genes in the olfactory system suggests mechanisms underlying COVID\u201019\u2010associated anosmia.Sci Adv.2020;6(31):eabc5801."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.03.031"},{"key":"e_1_2_9_6_1","unstructured":"Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID\u201019).https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/symptoms-testing\/symptoms.html. 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