{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:35:54Z","timestamp":1792067754328,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>To investigate the dynamic changes of Krebs von den Lungen\u20106 (KL\u20106) among patients with coronavirus disease 2019 (COVID\u201019) and the role of KL\u20106 as a noninvasive biomarker for predicting long\u2010term lung injury, the clinical information and laboratory tests of 166 COVID\u201019 patients were collected, and a correlation analysis between KL\u20106 and other parameters was conducted. There were 17 (10.2%, 17\/166) severe\/critical and 149 (89.8%, 149\/166) mild COVID\u201019 patients in our cohort. Serum KL\u20106 was significantly higher in severe\/critical COVID\u201019 patients than in mild patients (median 898.0 vs. 451.2\u2009U\/ml, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). KL\u20106 was next confirmed to be a sensitive and specific biomarker for distinguishing mild and severe\/critical patients and correlate to computed tomography lung lesions areas. Serum KL\u20106 concentration during the follow\u2010up period (&gt;100 days postonset) was well correlated to those concentrations within 10 days postonset (Pearson <jats:italic>r<\/jats:italic>\u2009=\u2009.867, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), indicating the prognostic value of KL\u20106 levels in predicting lung injury after discharge. Finally, elevated KL\u20106 was found to be significantly correlated to coagulation disorders, and T cells subsets dysfunctions. In summary, serum KL\u20106 is a biomarker for assessing COVID\u201019 severity and predicting the prognosis of lung injury of discharged patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26793","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:51:45Z","timestamp":1610697105000},"page":"2505-2512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Prognostic roles of KL\u20106 in disease severity and lung injury in COVID\u201019 patients: A longitudinal retrospective analysis"],"prefix":"10.1002","volume":"93","author":[{"given":"Kai","family":"Deng","sequence":"first","affiliation":[{"name":"Infectious Diseases Institute, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Fan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, 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