{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:50:06Z","timestamp":1777272606914,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974222"],"award-info":[{"award-number":["81974222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671386"],"award-info":[{"award-number":["81671386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Several descriptive studies have reported that higher neutrophil count (NC) may be correlated with poor prognosis in patients with confirmed COVID\u201019 infection. However, the findings from these studies are limited by methodology and data analysis. This study is a cohort study. We nonselectively and consecutively collected a total of 663 participants in a Chinese hospital from January 7 to February 28. Standardized and two\u2010piecewise Cox regression model were employed to evaluate the association between baseline neutrophil count (bNC), neutrophil count change rate (NCR), and death. bNC had a U\u2010shaped association with death. In the range of 0.1 to \u22641.49\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (hazard ratio [HR]\u2009=\u20090.19, 95% confidence interval [CI]\u2009=\u20090.05\u20130.66) and &gt;3.55\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L of bNC (HR\u2009=\u20092.82, 95% CI\u2009=\u20091.19\u20136.67), the trends on bNC with mortality were opposite. By recursive algorithm, the bNC at which the risk of the death was lower in the range of &gt;1.49 to \u22643.55\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (HR\u2009=\u200913.64, 95% CI\u2009=\u20090.25\u201374.71). In addition, we find that NCRs (NCR1 and NCR2) are\u00a0not associated with COVID\u201019\u2010related deaths. Compared with NCR, bNC has the potential to be used for early risk stratification in patients with COVID\u201019 infection. The relationship between bNC and mortality was U\u2010shaped. The safe range of bNC was 1.64\u20134.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Identifying the correlation may be helpful for early risk stratification and medical decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26794","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:32:46Z","timestamp":1611055966000},"page":"4265-4272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A U\u2010shaped association between baseline neutrophil count and COVID\u201019\u2010related mortality: A retrospective cohort study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-431X","authenticated-orcid":false,"given":"Wei","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology 925th Hospital of PLA Joint Logistics Support Force Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology GuiZhou University of Traditional Chinese Medicine Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Empower U, X&amp;Y solutions Inc. Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyuan","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Empower U, X&amp;Y solutions Inc. Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Empower U, X&amp;Y solutions Inc. Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songpu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Empower U, X&amp;Y solutions Inc. Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Empower U, X&amp;Y solutions Inc. Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 923th Hospital of PLA Joint Logistics Support Force Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Empower U, X&amp;Y solutions Inc. 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