{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:20:51Z","timestamp":1761582051491,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573211"],"award-info":[{"award-number":["81573211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The CRF01_AE and CRF07_BC clades dominate the human immunodeficiency virus (HIV) epidemics in China. Both clades have been identified in the men who have sex with men (MSM) population in Guangdong province, raising a serious concern of possible complex recombination events ahead. Here, we report the first case of CRF01_AE\/CRF07_BC recombinant sampled from a MSM patient in southern China. The genomic structure of this case is a mosaic with some regions resembling the CRF01_AE and CRF07_BC clades. Our phylogenetic analyses show that the two parental lineages of this recombinant virus were mainly found in the MSM population. This case has a different genomic composition compared with other recombinants descended from the same parental clades CRF01_AE and CRF07_BC. Our finding suggests that the MSM populations have become a hotspot for expanding viral diversity through the viral recombination mechanism. Therefore, further epidemiologic surveillance and monitoring should be conducted within the MSM populations to help advance our knowledge of viral transmission mechanisms. Additionally, these measures will serve to enhance the control and prevention of HIV\/acquired immunodeficiency syndrome in China.<\/jats:p>","DOI":"10.1002\/jmv.26799","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:34:00Z","timestamp":1610753640000},"page":"6383-6387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genomic characterization of a new CRF01_AE\/CRF07_BC case from a MSM patient in Guangdong, China"],"prefix":"10.1002","volume":"93","author":[{"given":"Xu\u2010He","family":"Huang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and Prevention  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolong","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Center for Disease Control and Prevention  Guangzhou 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