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Of the 91 participants initially testing positive, 86 participated in follow\u2010up approximately 14 days after study enrollment; of those 86 participants, 19 (22.1%) developed at least one symptom at any time after the initial positive severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) test result. The median number of days to symptom development after their initial positive test result was 6 (range 1\u201329 days). No participants reported a SARS\u2010CoV\u20102\u2010related hospitalization. The most frequently reported symptoms were fatigue or muscle aches (10.5%), headache (9.3%), fever (5.8%), and shortness of breath (5.8%). Of the 78 participants who submitted a nasopharyngeal swab for repeat RT\u2010PCR testing, 17 (21.8%) remained positive at Day 14, 4 of which continued to test positive at Day 28. These findings reinforce the probable role of silent SARS\u2010CoV\u20102 infections in community transmission, and that reliance on symptom development will miss a large proportion of infections. Broad testing programs not limited to individuals presenting with symptoms are critical for identifying persons with SARS\u2010CoV\u20102 infection and ultimately slowing transmission.<\/jats:p>","DOI":"10.1002\/jmv.26810","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:38:40Z","timestamp":1611056320000},"page":"2925-2931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Follow\u2010up of SARS\u2010CoV\u20102 positive subgroup from the Asymptomatic novel CORonavirus iNFection study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-5115","authenticated-orcid":false,"given":"Kristin J.","family":"Meyers","sequence":"first","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Dillman","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Williams","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Clifford","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris A.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady T.","family":"Botros","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Knorr","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Manner","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Woodward","sequence":"additional","affiliation":[{"name":"Lilly Research Labs, Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041225"},{"key":"e_1_2_10_3_1","unstructured":"Centers for Disease Control and Prevention. 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