{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:37:54Z","timestamp":1760027874906,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This critical appraisal aims to clarify which systematic reviews on COVID\u201019 treatment are based on high\u2010value evidence. Hereby, the most profitable medicines can be suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The mesh terms of \"COVID\u201019 drug treatment\" (Supplementary Concept) and \"COVID\u201019 drug treatment\" were sequentially utilized as search strategies in Medline and Science direct on October 18, 2020. Searches were confined to systematic reviews\/meta\u2010analyses. The Cochrane database was searched on November 1, 2020 with\u00a0\"COVID.\"\u00a0With adding up four articles from other resources, 84 systematic reviews were considered for initial screening. Finally, 22 articles fulfilled the criteria and were assessed using PRISMA guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increasing number of clinical trials from the onset of the COVID\u201019 pandemic has revealed that hydroxychloroquine and chloroquine are not only profitable but also deleterious. Lopinavir\/ritonavir failed to maintain their initial efficacy in improving clinical symptoms and mortality rate. Steroids and tocilizumab were suggested in patients with intensely severe symptoms. Steroids reduced mechanical ventilation and death in severely ill patients. Plasma or immunoglobulins effects are absolutely controversial. Favorable impressions of remdesivir have been relied on for the early onset of this drug. Hypotension and abnormal liver function tests were realized as its side effects. Favipiravir has resulted in a higher viral clearance than remdesivir. However, this claim needs to be proved with subsequent clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Currently, remdesivir and favipiravir are advantageous drugs that should be administered in the early phases. Their side effects are not well known and need to be found in the following research projects. Steroids and tocilizumab have been considered beneficial in the cytokine storm phase.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26811","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T12:03:15Z","timestamp":1611057795000},"page":"2705-2721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A complementary critical appraisal on systematic reviews regarding the most efficient therapeutic strategies for the current COVID\u201019 (SARS\u2010CoV\u20102) pandemic"],"prefix":"10.1002","volume":"93","author":[{"given":"Dorna","family":"Kheirabadi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Shiraz 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