{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:33:50Z","timestamp":1790220830652,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The coronavirus 2019 (COVID\u201019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), has spread across the world and is responsible for over 1,686,267 deaths worldwide. Co\u2010infection with influenza A virus (IFV\u2010A) during the upcoming flu season may complicate diagnosis and treatment of COVID\u201019. Little is known about epidemiology and outcomes of co\u2010infection. Data for 213 COVID\u201019 patients treated at Tongji Hospital in Wuhan from January 28, 2020 to March 24, 2020 were retrospectively analyzed. Ninety\u2010seven of the patients (45.5%) tested positive for anti\u2010 IFV\u2010A immunoglobulin M antibodies. The clinical characteristics were described and analyzed for patients with SARS\u2010CoV\u20102 infection only and patients with SARS\u2010CoV\u20102\/IFV\u2010A co\u2010infection. Patients with co\u2010infection showed similar patterns of symptoms and clinical outcomes to patients with SARS\u2010CoV\u20102 infection only. However, an increased expression of serum cytokines (interleukin\u20102R [IL\u20102R], IL\u20106, IL\u20108, and tumor necrosis factor\u2010\u03b1) and cardiac troponin I, and higher incidence of lymphadenopathy were observed in patients with SARS\u2010CoV\u20102 infection only. Male patients and patients aged\u2009less than\u200960 years in the SARS\u2010CoV\u20102 infection group also had significantly higher computed tomography scores than patients in co\u2010infection group, indicating that co\u2010infection with IFV\u2010A had no effect on the disease outcome but alleviated inflammation in certain populations of COVID\u201019 patients. The study will provide a reference for diagnosing and treating IFV\u2010A and SARS\u2010CoV\u20102 co\u2010infection cases in the upcoming flu season.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26817","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:45:13Z","timestamp":1611254713000},"page":"2947-2954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Co\u2010infection of influenza A virus and SARS\u2010CoV\u20102: A retrospective cohort study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-7424","authenticated-orcid":false,"given":"Yuan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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