{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:43Z","timestamp":1772118763877,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The implementation of rapid diagnostic tests (RDTs) may enhance the efficiency of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) testing, as RDTs are widely accessible and easy to use. The aim of this study was to evaluate the performance of a diagnosis strategy based on a combination of antigen and immunoglobulin M (IgM) or immunoglobulin G (IgG) serological RDTs. Plasma and nasopharyngeal samples were collected between 14 March and 11 April 2020 at hospital admission from 45 patients with reverse transcription polymerase chain reaction (RT\u2010PCR) confirmed COVID\u201019 and 20 negative controls. SARS\u2010CoV\u20102 antigen (Ag) was assessed in nasopharyngeal swabs using the Coris Respi\u2010Strip. For IgM\/IgG detection, SureScreen Diagnostics and Szybio Biotech RDTs were used in addition to laboratory assays (Abbott Alinity i SARS\u2010CoV\u20102 IgG and Theradiag COVID\u201019 IgM enzyme\u2010linked immunosorbent assay). Using the Ag RDT, 13 out of 45 (29.0%) specimens tested positive, the sensitivity was 87.0% for cycle threshold (\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      ) values \u226425% and 0% for\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      values greater than 25. IgG detection was associated with high\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                      values and the amount of time after the onset of symptoms. The profile of isolated IgM on RDTs was more frequently observed during the first and second week after the onset of symptoms. The combination of Ag and IgM\/IgG RDTs enabled the detection of up to 84.0% of COVID\u201019 confirmed cases at hospital admission. Antigen and antibody\u2010based RDTs showed suboptimal performances when used alone. However when used in combination, they are able to identify most COVID\u201019 patients admitted in an emergency department.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.26855","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T18:03:32Z","timestamp":1612807412000},"page":"3069-3076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Diagnosis value of SARS\u2010CoV\u20102 antigen\/antibody combined testing using rapid diagnostic tests at hospital admission"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-5039","authenticated-orcid":false,"given":"Nicolas","family":"Veyrenche","sequence":"first","affiliation":[{"name":"Pathogenesis and Control of Chronic Infections, INSERM, Etablissement Fran\u00e7ais du Sang, CHU Montpellier Universit\u00e9 de Montpellier  Montpellier 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