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To investigate the accuracy of APTIMA for cervical cancer screening in Japan, 423 subjects, mostly referrals with abnormal cytology or being followed up for cervical intraepithelial neoplasia (CIN)1, were screened using two HPV tests, hybrid capture 2 (HC2) and APTIMA, and by the Pap test. Colposcopy was conducted in all subjects with a positive result in either test type. HPV genotyping was performed by Genosearch\u201031.<\/jats:p><jats:p>A result of atypical squamous cells\u2010undetermined significance (ASC\u2010US) or worse on the HC2 test (ASC\u2010US\u2010HC2), and low\u2010grade squamous intraepithelial lesion (LSIL) or worse (LSIL+) on the Pap test, was regarded as positive. APTIMA (97.5%) was more sensitive than LSIL+ (85.1%) for detecting CIN2 or worse (CIN2+) (McNemar test; <jats:italic>p<\/jats:italic>\u2009=\u2009.0003), and more sensitive (98.6%) than ASC\u2010US\u2010HC2 (92.7%) for detecting CIN3+. APTIMA and HC2 had similar sensitivities. HPV genotyping revealed that CIN2\/3 with high\u2010risk HPV (HR\u2010HPV) was overlooked in five cases by ASC\u2010US\u2010HC2, and in four cases by HC2, while no such lesions were missed by APTIMA. Thus, APTIMA might be superior to HC2 for primary HPV screening in Japan. One cancer case positive for HPV67 (potentially high risk, [pHR]) was overlooked by Pap test and both HPV tests, suggesting a need for a new HPV test able to detect pHR\u2010HPV types.<\/jats:p>","DOI":"10.1002\/jmv.26865","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T06:42:18Z","timestamp":1614321738000},"page":"5076-5083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Aptima and hybrid capture\u20102 HPV tests and Pap test in the referral population in Japan"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-949X","authenticated-orcid":false,"given":"Hiroko","family":"Kuroki","sequence":"first","affiliation":[{"name":"Department of Gynecology Sakurajyuji Fukuoka Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-954X","authenticated-orcid":false,"given":"Jinichi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-9301","authenticated-orcid":false,"given":"Takeo","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-8691","authenticated-orcid":false,"given":"Masahiro","family":"Takakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-844X","authenticated-orcid":false,"given":"Toshiyuki","family":"Sasagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO"},{"key":"e_1_2_8_3_1","unstructured":"Cancer Registry and Statistics. 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