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Twenty\u2010four\u2010hour ambulatory blood pressure monitoring was performed if abnormal basal blood pressure. Patients were followed\u2010up for 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and sixteen\u00a0children were evaluated; 15 were finally included. Confirmed family member SARS\u2010CoV\u20102 infection was present in all. Twenty\u2010seven percent were asymptomatic. Anal and conjunctival swabs tests resulted negative in all. Patients with lower body mass index\u00a0(BMI) presented significantly higher viral loads. Main laboratory abnormalities were: lactate dehydrogenase increasing (73%), low vitamin D levels (87%), hematuria (33%), proteinuria (26%), renal hyperfiltration (33%), and hypofiltration (13%). Two of the patients with hyperfiltration exhibited high blood pressure levels at diagnosis, and persistence of prehypertension at 6\u2010month follow\u2010up. No abnormalities were seen at ultrasound, excepting for one patient who exhibited B\u2010lines at lung sonography. Immunoglobulin G seroconversion was observed in all at 1\u2010month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirm that intra\u2010family transmission is important. The significant higher viral loads recorded among patients with lower BMI, together with low vitamin D levels, support the impact of nutritional status on immune system. Renal involvement is frequent even among children with mild COVID\u201019, therefore prompt evaluation and identification of patients with reduced renal function reserve would allow a better stratification and management of patients. Seroconversion occurs also in asymptomatic children, with no differences in antibodies titer according to age, sex and clinical manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26871","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:28:17Z","timestamp":1613269697000},"page":"3122-3132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The comprehensive clinic, laboratory, and instrumental evaluation of children with COVID\u201019: A 6\u2010months prospective study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-5371","authenticated-orcid":false,"given":"Sara","family":"Isoldi","sequence":"first","affiliation":[{"name":"Maternal and Child Health Department,\u00a0Santa Maria Goretti Hospital Sapienza\u2014University of Rome  Latina Italy"},{"name":"Maternal and Child Health Department,\u00a0Pediatric Gastroenterology and 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