{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:20Z","timestamp":1772118800534,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) pandemic has become a major public health issue worldwide. Developing and evaluating rapid and easy\u2010to\u2010perform diagnostic tests is a high priority. The current study was designed to assess the diagnostic performance of an antigen\u2010based rapid detection test (COVID\u2010VIRO\u00ae) in a real\u2010life setting.\u00a0Two nasopharyngeal specimens of symptomatic or asymptomatic adult patients hospitalized in the Infectious Diseases Department or voluntarily accessing the COVID\u201019 Screening Department of the Regional Hospital of Orl\u00e9ans, France, were concurrently collected. The diagnostic specificity and sensitivity of COVID VIRO\u00ae results were compared to those of real\u2010time reverse\u2010transcriptase quantitative polymerase chain reaction (RT\u2010qPCR) results. A subset of patients underwent an additional oropharyngeal and\/or saliva swab for rapid testing.\u00a0A total of 121 patients confirmed to be infected and 127 patients having no evidence of recent or ongoing infection were enrolled for a total of 248 nasopharyngeal swab specimens. Overall, the COVID\u2010VIRO\u00ae sensitivity was 96.7% (CI, 93.5%\u201399.9%). In asymptomatic patients, symptomatic patients having symptoms for more than 4 days and those with an RT\u2010qPCR cycle threshold value\u2009\u2265\u200932, the sensitivities were 100%, 95.8%, and 91.9%, respectively. The concordance between RT\u2010qPCR and COVID VIRO\u00ae rapid test results was 100% for the 127 patients with no SARS\u2010CoV\u20102 infection.\u00a0The COVID\u2010VIRO\u00ae test had 100% specificity and sensitivity greater than 95%, which are better than the recommendations set forth by the WHO (specificity\u2009\u2265\u200997%\u2013100%, sensitivity\u2009\u2265\u200980%). These rapid tests may be particularly useful for large\u2010scale screening in emergency departments, low\u2010resource settings, and airports.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.26896","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T21:44:36Z","timestamp":1613943876000},"page":"3152-3157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["High performance of a novel antigen detection test on nasopharyngeal specimens for diagnosing SARS\u2010CoV\u20102 infection"],"prefix":"10.1002","volume":"93","author":[{"given":"L.","family":"Courtellemont","sequence":"first","affiliation":[{"name":"Department of Virology CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Guinard","sequence":"additional","affiliation":[{"name":"Department of Virology CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Guillaume","sequence":"additional","affiliation":[{"name":"Department of Virology CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Giach\u00e9","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases CHR Orleans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Rzepecki","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases CHR Orleans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Seve","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases CHR Orleans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gubavu","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases CHR Orleans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Baud","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases CHR Orleans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Le Helloco","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases CHR Orleans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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