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The present study investigated the frequency of cytomegalovirus (CMV), Epstein\u2010Barr virus (EBV), and papillomavirus types 6 and 11 (HPV6 and HPV11), their impact on clinical manifestations of cardiovascular diseases, and their possible association with inflammation in patients with AAA and healthy volunteers. Genotyping of CMV <jats:italic>UL75<\/jats:italic>, EBV <jats:italic>LMP\u20101<\/jats:italic>, and HPV6, and HPV11 <jats:italic>E6<\/jats:italic> was performed by polymerase chain reaction (PCR), while the viral DNA loads were measured by quantitative real\u2010time PCR. Cytokine levels were determined by enzyme\u2010linked immunosorbent assays. The CMV <jats:italic>UL75<\/jats:italic> was detected more frequently in the blood of patients with AAA than in the blood of healthy volunteers (32.7% vs. 6.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). Neither EBV <jats:italic>LMP\u20101<\/jats:italic> nor HPV6 <jats:italic>E6<\/jats:italic> was found in blood and aortic wall biopsies, while the HPV11 <jats:italic>E6<\/jats:italic> was detected in 36.4% of AAA walls. The CMV infection in patients with AAA was associated with an increased risk of hypertension and coronary artery disease\u00a0(OR, 9.057; 95% CI, 1.141\u201371.862; <jats:italic>p<\/jats:italic>\u2009=\u2009.037;\u00a0and OR, 2.575; 95% CI, 1.002\u20136.615; <jats:italic>p<\/jats:italic>\u2009=\u2009.049, respectively). Additionally, CMV\u2010infected patients with AAA had higher tumor necrosis factor\u2010\u03b1 levels compared with noninfected subjects (<jats:italic>p<\/jats:italic>\u2009=\u2009.017). Our findings suggest that CMV infection can stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms.<\/jats:p>","DOI":"10.1002\/jmv.26901","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T10:00:38Z","timestamp":1614247238000},"page":"5017-5024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Abdominal aortic aneurysm and virus infection: A potential causative role for cytomegalovirus infection?"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-043X","authenticated-orcid":false,"given":"Agnieszka","family":"Jab\u0142o\u0144ska","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Institute of Medical Biology Polish Academy of Sciences  Lodz 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