{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:19Z","timestamp":1786978039345,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T00:00:00Z","timestamp":1615680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Crimean Congo hemorrhagic fever (CCHF) is one of the most important viral infections and is caused by\n                    <jats:italic>Crimean Congo hemorrhagic fever orthonairovirus<\/jats:italic>\n                    (CCHFV). Severity of CCHF can vary from a mild and nonspecific illness\u00a0to a severe disease with fatal outcomes. MicroRNAs (miRNAs) have an increasing impact on the different pathways of viral infections. Within the transition process from acute phase to convalescence with 18 CCHF patients, we investigated the impacts on miRNA via microarray for the first time. We also compared miRNA gene expression in 16 severe and 15 mild cases. We identified Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) pathways associated with significant miRNAs utilizing DIANA TOOLS mirPath v.3. In this study, miR\u201015b\u20105p and miR\u201029a\u20103p were significantly downregulated in statistical terms; miR\u20104741, miR\u2010937\u20105p, miR\u20106068, miR\u20107110\u20105p, miR\u20106126, and miR\u20107107\u20105p were upregulated in acute cases in comparison with convalescent patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u2009.05).\u00a0In total, 28 miRNAs (8 downregulated, 20 upregulated) were differentially expressed in severe CCHF patients as compared with mild cases (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u2009.05). Whereas miR\u20106732\u20103p, miR\u20104436b\u20105p, miR\u2010483\u20103p, and miR\u20106807\u20105p had the highest downregulation,\u00a0miR\u2010532\u20105p, miR\u2010142\u20105p, miR\u201029c\u20103p, and let\u20107f\u20105p had the highest upregulation in severe patients in comparison with mild cases. Consequently, we determined that CCHF\u2010induced miRNAs are associated with antiviral and proinflammatory pathways in acute and severe cases. In comparison with convalescence, these miRNAs in acute period may be therapeutic targets.\n                  <\/jats:p>","DOI":"10.1002\/jmv.26909","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T01:36:10Z","timestamp":1614562570000},"page":"4729-4737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["MicroRNA analysis from acute to convalescence in Crimean Congo hemorrhagic fever"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3921-8061","authenticated-orcid":false,"given":"Serdal","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Medical Biology Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-457X","authenticated-orcid":false,"given":"Burcu","family":"Bayyurt","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-8793","authenticated-orcid":false,"given":"Aynur","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,14]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"97","article-title":"Transfusion therapy: an overview","volume":"8","author":"Al Mussaed E","year":"2018","journal-title":"J Adv Pharm Edu 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