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An increasing number of publications highlight the role of Transmembrane Serine Protease 2 (<jats:italic>TMPRSS2<\/jats:italic>) in the susceptibility of the host cell to SARS\u2010CoV\u20102. Cleavage of viral spike protein via the host cell's TMPRSS2 enzyme activity mediates viral entry into the host cell. The enzyme synthesis is regulated by the\u00a0<jats:italic>TMPRSS2<\/jats:italic> gene, which has also been implicated in the entry mechanisms of previously reported Coronavirus infections. In this review, we have investigated the pathogenicity of SARS\u2010CoV\u20102 and disease susceptibility dependence on the\u00a0<jats:italic>TMPRSS2<\/jats:italic> gene as expressed in various population groups. We further discuss how the differential expression of this gene in various ethnic groups can affect the SARS\u2010CoV\u20102 infection and Coronavirus disease (COVID)\u201019 outcomes. 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