{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:55:36Z","timestamp":1791064536993,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hantavirus cardiopulmonary syndrome (HCPS) has a high lethality. Severe cases may be rescued by venoarterial extracorporeal membrane oxygenation (VA ECMO), alongside substantial complications. High volume hemofiltration (HVHF) is a depurative technique that provides homeostatic balance allowing hemodynamic stabilization in some critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We implemented HVHF before VA ECMO consideration in the last five severe HCPS patients requiring mechanical ventilation and vasoactive drugs admitted to our intensive care unit. Patients were considered HVHF\u2010responders if VA ECMO was avoided and HVHF\u2010nonresponders if VA ECMO support was needed despite HVHF. A targeted\u2010HVHF strategy compounded by aggressive hyperoncotic albumin, sodium bicarbonate, and calcium supplementation plus ultrafiltration to avoid fluid overload was implemented on three patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients had maximum serum lactate of 8.8 (8.7\u201312.8)\u2009mmol\/L and a lowest cardiac index of 1.8 (1.8\u20131.9)\u2009L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      . The first two required VA ECMO. They were connected later to HVHF, displayed progressive tachycardia and declining stroke volume. The opposite was true for HVHF\u2010responders who received targeted\u2010HVHF. All patients survived, but one of the VA ECMO patients suffered a vascular complication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HVHF may contribute to support severe HCPS patients avoiding the need for VA ECMO in some. Early connection and targeted\u2010HVHF may increase the chance of success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.26930","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T05:34:58Z","timestamp":1615527298000},"page":"4738-4747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Targeted high volume hemofiltration could avoid extracorporeal membrane oxygenation in some patients with severe Hantavirus cardiopulmonary syndrome"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-6367","authenticated-orcid":false,"given":"Ren\u00e9","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Departamento de Paciente Cr\u00edtico Cl\u00ednica Alemana de Santiago  Santiago Chile"},{"name":"Carrera de Medicina, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo  Santiago 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