{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:32:32Z","timestamp":1744313552364,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of direct\u2010acting antiviral agents (DAAs) in patients with chronic HCV genotype (GT) 1 infection results in sustained virologic response (SVR) rates of 95%\u201397%, but 3%\u20135% of patients experience virologic failure. We observed 41 patients infected with HCV subtype 1b who failed previous treatment with DAAs, including 37 subjects (90.2%) with liver cirrhosis. In total, 30 (73.2%) subjects previously received NS5A inhibitors of the first generation (ledipasvir, daclatasvir, or ombitasvir) and 11 subjects (26.8%) received NS5A inhibitors of the second generation (velpatasvir). All patients received retreatment with a combination of ombitasvir\/paritaprevir\/ritonavir and dasabuvir (3D) with sofosbuvir (SOF) and ribavirin (RBV). We compared SVR12 rates depending on fibrosis stage, presence of just single or double NS5A mutation (L31M\/V\/I and\/or Y93H), and the generation of previously used NS5A inhibitors. Observed SVR12 rates were as follows: 97.6% (40\/41 patients) overall; 100% in patients without cirrhosis (<jats:italic>n<\/jats:italic>\u2009=\u20094) versus 97.3% in those with cirrhosis (<jats:italic>n<\/jats:italic>\u2009=\u200937); 100% with single L31M\/V\/I or Y93H mutation (<jats:italic>n<\/jats:italic>\u2009=\u200922) versus 94.4% with double mutations (<jats:italic>n<\/jats:italic>\u2009=\u200918); 100% in patients who failed previous treatment with first\u2010generation (<jats:italic>n<\/jats:italic>\u2009=\u200930) versus 90.9% in those who failed\u00a0previous treatment with second\u2010generation NS5A inhibitors (<jats:italic>n<\/jats:italic>\u2009=\u200911). Retreatment with 3D\u2009+\u2009SOF\u2009+\u2009RBV was highly effective and safe in patients with chronic HCV GT1b infection, including those with liver cirrhosis, who failed\u00a0previous treatment with\u00a0DAA containing NS5A inhibitors. Fibrosis stage and single or simultaneous presence of NS5A RASs L31M\/V\/I and Y93H at the baseline, as well as the generation of previously used NS5A inhibitors, did not impact SVR12 rates.<\/jats:p>","DOI":"10.1002\/jmv.26935","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T10:59:49Z","timestamp":1615460389000},"page":"4975-4981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of retreatment with ombitasvir\/paritaprevir\/ritonavir and\u00a0dasabuvir+sofosbuvir+ribavirin in patients with chronic hepatitis C, subtype 1b, and cirrhosis, who failed previous\u00a0treatment with first\u2010 and second\u2010generation NS5A inhibitors"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-7072","authenticated-orcid":false,"given":"Sergii V.","family":"Fedorchenko","sequence":"first","affiliation":[{"name":"Department of Viral Hepatitis and AIDS The L.V. Gromashevskyi Institute of Epidemiology and Infectious Disease  Kiev Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Martynovych","sequence":"additional","affiliation":[{"name":"Department of Viral Hepatitis and AIDS The L.V. Gromashevskyi Institute of Epidemiology and Infectious Disease  Kiev Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanna","family":"Klimenko","sequence":"additional","affiliation":[{"name":"Department of Viral Hepatitis and AIDS The L.V. Gromashevskyi Institute of Epidemiology and Infectious Disease  Kiev Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Solianyk","sequence":"additional","affiliation":[{"name":"Department of Viral Hepatitis and AIDS The L.V. Gromashevskyi Institute of Epidemiology and Infectious Disease  Kiev Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12473"},{"key":"e_1_2_8_3_1","first-page":"161","article-title":"Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modeling study","volume":"2","author":"Black S","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_8_4_1","first-page":"270","volume-title":"Chronic HCV\u2010Infection","author":"Fedorchenko SV","year":"2010"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"17","article-title":"Treatment of patient with chronic hepatitis C infection in Lombardia: a report by the Lombardia Hepatitis Network","volume":"20","author":"Aghemo A","year":"2016","journal-title":"Eur\u00a0Rev\u00a0Med\u00a0Pharmacol\u00a0Sci"},{"key":"e_1_2_8_6_1","first-page":"1136","article-title":"Effectiveness, safety and clinical outcomes of direct\u2010acting antiviral therapy in HCV genotype 1 infection: results from a Spanish real\u2010world cohort","volume":"66","author":"Crespo J","year":"2017","journal-title":"J Hepatol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(15)30980-6"},{"key":"e_1_2_8_8_1","unstructured":"DeterdingK.Failure is a rare event in DAAs era even in cirrhotic: large real\u2010world date confirm clinical trial results: cirrhotic patients. 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