{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:32Z","timestamp":1740104132501,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The chronicity or clearance of hepatitis B virus (HBV) infection depends on viral and genetic variables. The immune response against HBV is thought to be responsible for viral persistence or clearance. Cytokines such as interleukin 1\u20102B (IL1\u20102B) involved in the T\u2010helper 1 system are key mediators in the defence mechanisms against viral infection and play a role in the regulation of HBV clearance during infection. We aimed to examine whether the polymorphic variant TaqI polymorphism in the 3\u2032\u2010untranslated region (3\u2032\u2010UTR; rs3212227) suspected to modulate interleukin\u2010levels of IL\u201012B has an influence on the risk of development of chronicity after HBV exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genotyping was performed by the polymerase chain reaction\u2010restriction fragment length polymorphism method for 236 patients with chronic hepatitis B (CHB) and 240 controls from different cities of Tunisia recruited in the Pasteur Institute of Tunisia between January 2017 and December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the <jats:italic>IL\u201012B<\/jats:italic> polymorphism was associated with a significantly increased risk of CHB in patients (<jats:italic>p<\/jats:italic>\u2009=\u20091\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200910.31 and odds ratio [OR]\u2009=\u20092.14; 95% confidence interval [CI]\u2009=\u20091.30\u20133.52) when AC\/CC variant genotypes were compared with the wild\u2010type AA homozygote. Statistical significance was found when CHB\u2010males were compared with CHB\u2010females (<jats:italic>p<\/jats:italic>\u2009=\u20092\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200926.62 and <jats:italic>p<\/jats:italic>\u2009=\u20091\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200910.36, for genotypic and allelic frequencies, respectively). Also, CHB\u2010patients carrying C\u2010allele less than 50\u2010years were at an increased risk of\u00a0developing chronic HBV infection than patients more than 50\u2010years (<jats:italic>p<\/jats:italic>\u2009=\u20096.1\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200916.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the C\u2010allele would affect susceptibility to chronicity after HBV exposure in Tunisian patients especially for males less than 50\u2010years. Age and sex have an influence on this polymorphism in CHB Tunisian patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26946","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T10:53:07Z","timestamp":1616151187000},"page":"4949-4956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Strong association of functional polymorphism in <i>IL\u201012B<\/i> with susceptibility to chronic hepatitis B in Tunisia"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-3339","authenticated-orcid":false,"given":"Im\u00e8ne","family":"Ben Dhifallah","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Virology, Pasteur Institute of Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0872-5706","authenticated-orcid":false,"given":"Kaouther","family":"Ayouni","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Pasteur Institute of Tunis University of Tunis El Manar  Tunis Tunisia"},{"name":"Faculty of Sciences of Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa","family":"Jmel","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics, Pasteur Institute Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Kammoun","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics, Regional Training Center supported by WHO\u2010TDR for East Mediterranean Region (EMR) Pasteur Institute  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Hamzaoui","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences\u00a0Histology, Immunology and cell Biology, Faculty of Medicine of Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Sadraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Pasteur Institute of Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henda","family":"Triki","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Pasteur Institute of Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO. 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