{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:22:46Z","timestamp":1792650166603,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda","doi-asserted-by":"publisher","award":["2019\u20101\u201032"],"award-info":[{"award-number":["2019\u20101\u201032"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To date, mother\u2010to\u2010fetus transmission of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), responsible for the coronavirus disease 2019 (COVID\u201019) pandemic, remains controversial. Although placental COVID\u201019 infection has been documented in some cases during the second\u2010 and third\u2010trimesters, no reports are available for the first trimester of pregnancy, and no SARS\u2010CoV\u20102 protein has been found in fetal tissues. We studied the placenta and fetal organs from an early pregnancy miscarriage in a COVID\u201019 maternal infection by immunohistochemical, reverse transcription quantitative real\u2010time polymerase chain reaction, immunofluorescence, and electron microscopy methods. SARS\u2010CoV\u20102 nucleocapsid protein, viral RNA, and particles consistent with coronavirus were found in the placenta and fetal tissues, accompanied by RNA replication revealed by double\u2010stranded RNA (dsRNA) positive immunostain. Prominent damage of the placenta and fetal organs were associated with a hyperinflammatory process identified by histological examination and immunohistochemistry. The findings provided in this study document that congenital SARS\u2010CoV\u20102 infection is possible during the first trimester of pregnancy and that fetal organs, such as lung and kidney, are targets for coronavirus. The infection and multi\u2010organic fetal inflammation produced by SARS\u2010CoV\u20102 during early pregnancy should alert clinicians in the assessment and management of pregnant women for possible fetal consequences and adverse perinatal outcomes.<\/jats:p>","DOI":"10.1002\/jmv.26965","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T10:49:38Z","timestamp":1616669378000},"page":"4480-4487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Fetal and placental infection with SARS\u2010CoV\u20102 in early pregnancy"],"prefix":"10.1002","volume":"93","author":[{"given":"Mar\u00eda Y.","family":"Valdespino\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Departamento de Patolog\u00eda Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia 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