{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:14:47Z","timestamp":1740104087153,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The aim is to comparatively evaluate the results of simultaneous conjunctiva and oropharynx\u2013nasopharynx (ONP) swabs in patients who had presented to the outpatient department with a suspicion of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). An ONP sample was obtained following bilateral conjunctiva swabs in 85 subjects with a contact history or symptoms but unknown SARS\u2010CoV\u20102 status and with no ocular symptoms or findings. The results were evaluated according to the patient's symptoms and how the swab was taken. The conjunctiva swab was positive in 29 (34.1%) cases and the ONP swab in 20 (23.5%) cases. Both methods produced positive results in 11 (14.1%) cases. The mean cycle threshold (<jats:italic>C<\/jats:italic><jats:sub>t<\/jats:sub>) value was 30.15\u2009\u00b1\u20093.41 in symptomatic cases and 33.62\u2009\u00b1\u20091.76 in asymptomatic cases (<jats:italic>p<\/jats:italic>\u2009=\u2009.008). The mean <jats:italic>C<\/jats:italic><jats:sub>t<\/jats:sub> value was 24.37\u2009\u00b1\u20093.48 when only the ONP swab was positive and 31.22\u2009\u00b1\u20091.99 when only the conjunctiva swab was positive. In cases that were positive by both methods, the mean <jats:italic>C<\/jats:italic><jats:sub>t<\/jats:sub> value was 25.21\u2009\u00b1\u20094.94 for the ONP swab and 30.29\u2009\u00b1\u20095.05 for the conjunctiva swab.\u00a0We found higher SARS\u2010CoV\u20102 detection rates with the conjunctiva swab than the ONP swab in cases with unknown SARS\u2010CoV\u20102 status in the early period. In addition, the conjunctival viral load seemed to be higher in symptomatic cases than in asymptomatic cases. We, therefore, believe a conjunctiva swab could be an alternative method to detect SARS\u2010CoV\u20102 at the time of the first presentation to the outpatient department.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.26981","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T10:44:16Z","timestamp":1617101056000},"page":"4516-4522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the simultaneous conjunctiva and oropharynx\u2013nasopharynx swab results in patients applying to the SARS\u2010CoV\u20102 outpatient clinic for the first time"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-9978","authenticated-orcid":false,"given":"Ayten","family":"Gunduz","sequence":"first","affiliation":[{"name":"Department of Medical Microbology, Faculty of Medicine Malatya Turgut Ozal University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-9332","authenticated-orcid":false,"given":"Murat","family":"Firat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Elbistan State Hospital Elbistan Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Turkoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbology, Faculty of Medicine Malatya Turgut Ozal University Malatya Turkey"},{"name":"Department of Medical Microbology Malatya Training and Research Hospital Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1772314"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30313-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1775261"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.13224"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.04.028"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"149","article-title":"There is a role in detection of SARS\u2010CoV\u20102 in conjunctiva and tears: a comprehensive review","volume":"43","author":"Bernabei F","year":"2020","journal-title":"New Microbiol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.03.026"},{"key":"e_1_2_8_9_1","first-page":"1","article-title":"What is the significance of the conjunctiva as a potential transmission route for SARS\u2010CoV\u20102 infections?","volume":"118","author":"Lange C","year":"2020","journal-title":"Der Ophthalmologe"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14412"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2020.03.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1287_20"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S270006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.035931"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.08.029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001737"},{"issue":"18","key":"e_1_2_8_17_1","first-page":"1843","article-title":"Detection of SARS\u2010CoV\u20102 in different types of clinical specimens","volume":"323","author":"Wang W","year":"2020","journal-title":"JAMA"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00791"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2020.8.48420"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25892"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06402-z"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2004973"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120976548"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2020.04.006"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.26981","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T05:47:04Z","timestamp":1720504024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jmv.26981"],"URL":"https:\/\/doi.org\/10.1002\/jmv.26981","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2021-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}