{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:37:08Z","timestamp":1774525028674,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["442776\/2019\u20105 and FAPESP 2018\/14384\u20109"],"award-info":[{"award-number":["442776\/2019\u20105 and FAPESP 2018\/14384\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One year into the coronavirus disease 2019 (COVID\u201019) pandemic, diagnostic strategies, although central for contact tracing and other preventive measures, are still limited. To meet the global demand, lower cost and faster antigen tests for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) detection are a convenient alternative to the gold standard reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) assay. We tested laboratory\u2010based RT\u2010PCR RNA detection and two rapid antigen detection (RAD) tests, based on the immunochromatography test for nucleocapsid protein of SARS\u2010CoV\u20102 (COVID\u201019 Ag ECO Test, ECO Diagn\u00f3stica, and Panbio COVID\u201019 Ag Rapid Test Abbott). Paired collection and testing were done in a small prospective open study in three clinical services in S\u00e3o Paulo, constituted of mostly symptomatic volunteers at collection (97%, 109\/112) for a median of 4 days (interquartile range: 3\u20136), ranging from 1 to 30. Among the 108 paired RT\u2010PCR\/RAD tests, results were concordant in 96.4% (101\/108). The test's performance was comparable, with an overall sensitivity of 87% and a specificity of 96%. These observations add to other data that suggest that antigen tests may provide reasonable sensitivity and specificity and deserve a role to improve testing strategies, especially in resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/jmv.26985","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T10:59:10Z","timestamp":1617188350000},"page":"4405-4410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Field evaluation of COVID\u201019 antigen tests versus RNA based detection: Potential lower sensitivity compensated by immediate results, technical simplicity, and low cost"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-4154","authenticated-orcid":false,"given":"Elaine Monteiro","family":"Matsuda","sequence":"first","affiliation":[{"name":"Infectious Diseases Outpatient Clinic Santo Andr\u00e9 Health Secretary Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-0572","authenticated-orcid":false,"given":"Ivana Barros","family":"de Campos","sequence":"additional","affiliation":[{"name":"Santo Andr\u00e9 Regional Center Adolfo Lutz Institute Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-0443","authenticated-orcid":false,"given":"Isabela Penteriche","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Bioprocess and Biotecnology Engeneering S\u00e3o Paulo State University Botucatu S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Rodrigues","family":"Colpas","sequence":"additional","affiliation":[{"name":"Santo Andr\u00e9 Regional Center Adolfo Lutz Institute Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-4623","authenticated-orcid":false,"given":"Andreia Moreira dos Santos","family":"Carmo","sequence":"additional","affiliation":[{"name":"Santo Andr\u00e9 Regional Center Adolfo Lutz Institute Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-7837","authenticated-orcid":false,"given":"Lu\u00eds Fernando de Macedo","family":"Br\u00edgido","sequence":"additional","affiliation":[{"name":"Virology Center Adolfo Lutz Institute S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104654"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15927.1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02589-20"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"key":"e_1_2_10_6_1","unstructured":"Centers for Disease Control and Prevention (CDC). 2019\u2010Novel coronavirus (2019\u2010nCoV) real\u2010time rRT\u2010PCR panel primers and probes. 2020.https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/downloads\/rt-pcr-panel-primer-probes.pdf"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.11.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104659"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.01.06.21249282"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.09.20056325"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104500"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243597"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa377"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_2987_20"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.2020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1227"},{"key":"e_1_2_10_17_1","unstructured":"Minist\u00e9rio da Sa\u00fade Secretaria Executiva Gabinete da Secretaria Executiva. Orienta\u00e7\u00f5es para manuseio medicamentoso precoce de pacientes com diagn\u00f3stico da COVID\u201019. Nota informativa N\u00b0 9\/2020\u2010SE\/GAB\/SE\/MS 2020.https:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2020\/May\/21\/Nota-informativa---Orienta----es-para-manuseio-medicamentoso-precoce-de-pacientes-com-diagn--stico-da-COVID-19.pdf"},{"key":"e_1_2_10_18_1","unstructured":"WHO. COVID\u201019 target product profiles for priority diagnostics to support response to the COVID\u201019 pandemic v.1.0. 2020.https:\/\/www.who.int\/publications\/m\/item\/covid-19-target-product-profiles-for-priority-diagnostics-to-support-response-to-the-covid-19-pandemic-v.0.1"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.26985","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T05:47:16Z","timestamp":1720504036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jmv.26985"],"URL":"https:\/\/doi.org\/10.1002\/jmv.26985","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"2021-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}