{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:21:39Z","timestamp":1769116899905,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The relation between severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection and demyelinating Guillain\u2010Barre syndrome (GBS) has been defined. We aim to report the clinical features of a child with axonal GBS associated with SARS\u2010CoV\u20102.\u00a0A 6\u2010year\u2010old male presented with symmetric ascending paralysis progressed over a 4\u2010day course and 2 days of fever. He had bilateral lower and upper limb flaccid weakness of 1\/5 with absent deep tendon reflexes. He had severe respiratory muscle weakness requiring invasive mechanical ventilation. On admission, SARS\u2010CoV\u20102 returned as positive by real\u2010time polymerase chain reaction on a nasopharyngeal swab. Cerebrospinal fluid analysis showed elevated protein without pleocytosis. He was diagnosed with GBS associated with SARS\u2010CoV\u20102 infection. The nerve conduction study was suggestive of acute motor axonal neuropathy. Ten consecutive therapeutic plasma exchange sessions with 5% albumin replacement followed by four sessions on alternate days were performed. On Day 12, methylprednisolone (30\u2009mg\/kg\/day for 5 days) was given. On Day 18, intravenous immunoglobulin\u00a0(2\u2009g\/kg\/day) was given and repeated 14 days after due to severe motor weakness. On Day 60, he was discharged from the hospital with weakness of neck flexor and extensor muscles of 3\/5 and the upper limbs and the lower limbs of 2\/5 on home\u2010ventilation.\u00a0Our patient is considered to be the youngest patient presenting with a possible para\u2010infectious association between axonal GBS and SARS\u2010CoV\u20102 infection. The disease course was severe with a rapid progression, an earlier peak, and prolonged duration in weakness as expected in axonal GBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27018","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:46:43Z","timestamp":1618447603000},"page":"5599-5602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Axonal Guillain\u2010Barre syndrome associated with SARS\u2010CoV\u20102 infection in a child"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-2226","authenticated-orcid":false,"given":"Nihal","family":"Ak\u00e7ay","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, Bakirkoy Dr Sadi Konuk Education and Research Hospital University of the Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3839-4722","authenticated-orcid":false,"given":"Mehmet Emin","family":"Menento\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Bakirkoy Dr Sadi Konuk Education and Research Hospital University of the Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-3964","authenticated-orcid":false,"given":"Gonca","family":"Bekta\u015f","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, Bakirkoy Dr Sadi Konuk Education and Research Hospital University of the Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-2877","authenticated-orcid":false,"given":"Esra","family":"\u015eevketo\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Bakirkoy Dr Sadi Konuk Education and Research Hospital University of the Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"World Health Organization (WHO)Coronavirus disease (COVID\u201019) dashboard. 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