{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:50:42Z","timestamp":1774529442957,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>With\u00a0the perspective of prophylactic vaccination against high\u2010risk human papillomavirus (HPV), we analyzed the viral epidemiology of cervical neoplasia in Senegal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients were treated at the Institut Joliot Curie du Cancer in Dakar. HPV genotypes were characterized using a real\u2010time polymerase chain reaction\u2010based approach and sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histologically, there were 224 invasive carcinomas, 17 high\u2010grade intraepithelial neoplasia (CIN), and five undetermined histologies. Molecular analysis was conclusive in 241 cases. HPV DNA was found in 207\/241 (85.9%) cases while 34\/241 (14.1%) remained HPV negative. There was one single genotype in 127\/207 (61.4%) cases and several in 80\/207 (38.6%) corresponding to 308 genotypes identified. Viral genotyping found HPV16 in 175 (56.8%) cases, HPV18 in 45 (14.6%), HPV45 in 40 (13.0%), HPV58 in 35 (11.4%), HPV33 in 6 (2.0%), HPV35 in 3 (1.0%), HPV31 in 2 (0.6%), HPV39 and HPV56 in one (0.3% each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our analysis showed that 98.4% of the HPV\u2010positive cases were associated with viral genotypes covered by the 9\u2010valent HPV vaccine. However, 14.1% of cases remained HPV negative. Therefore, prophylactic vaccination using a 9\u2010valent vaccine should dramatically reduce the incidence of HPV\u2010associated neoplasia but the detection and treatment of CIN remain necessary for the optimal prevention of cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27020","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:46:32Z","timestamp":1618447592000},"page":"5110-5117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Respective prevalence of high\u2010risk HPVgenotypes in cervical neoplasia in Senegal"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-5448","authenticated-orcid":false,"given":"Halimatou","family":"Diop\u2010Ndiaye","sequence":"first","affiliation":[{"name":"Bacteriology\u2010Virology Laboratory at CHU Aristide Le Dantec,\u00a0Aristide Le Dantec Hospital Cheikh Anta Diop University of Dakar  Dakar S\u00e9n\u00e9gal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Sastre\u2010Garau","sequence":"additional","affiliation":[{"name":"Department of Pathology Intercommunal Hospital Center of Cr\u00e9teil  Cr\u00e9teil Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aboubacry","family":"Drame","sequence":"additional","affiliation":[{"name":"Bacteriology\u2010Virology Laboratory at CHU Aristide Le Dantec,\u00a0Aristide Le Dantec Hospital Cheikh Anta Diop University of Dakar  Dakar S\u00e9n\u00e9gal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birama","family":"Dembele","sequence":"additional","affiliation":[{"name":"Juliot Curie Institute, CHU Aristide Le Dantec Cheikh Anta Diop University of Dakar  Dakar S\u00e9n\u00e9gal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafissatou N.","family":"Ba","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomo\u2010Pathology, CHU Aristide Le Dantec Cheikh Anta Diop University of Dakar  Dakar S\u00e9n\u00e9gal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumy","family":"Diop\u2010Diongue","sequence":"additional","affiliation":[{"name":"Bacteriology\u2010Virology Laboratory at CHU Aristide Le Dantec,\u00a0Aristide Le Dantec Hospital Cheikh Anta Diop University of Dakar  Dakar S\u00e9n\u00e9gal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Mbow","sequence":"additional","affiliation":[{"name":"Juliot Curie Institute, CHU Aristide Le Dantec Cheikh Anta Diop University of Dakar  Dakar S\u00e9n\u00e9gal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mba E. 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