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This study focused on the possible association between lymphopenia and computed tomography (CT) scan features and COVID\u201019 patient mortality. The clinical data of 596 COVID\u201019 patients were collected from February 2020 to September 2020. The patients' serological survey and CT scan features were retrospectively explored.\u00a0The median age of the patients was 56.7\u2009\u00b1\u200916.4 years old. Lung involvement was more than 50% in 214 COVID\u201019 patients (35.9%). The average blood lymphocyte percentage was 20.35\u2009\u00b1\u200910.16 (normal range, 20%\u201350%). Although the levels of C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were high in more than 80% of COVID\u201019 patients; CRP, ESR, and platelet\u2010to\u2010lymphocyte ratio (PLR) may not indicate the in\u2010hospital mortality of COVID\u201019. Patients with severe lung involvement and lymphopenia were found to be significantly associated with increased odds of death (odds ratio, 9.24; 95% confidence interval, 4.32\u201319.78). These results indicated that lymphopenia\u2009&lt;\u200920% along with pulmonary involvement &gt;50% impose a multiplicative effect on the risk of mortality. The in\u2010hospital mortality rate of this group was significantly higher than other COVID\u201019 hospitalized cases. Furthermore, they meaningfully experienced a prolonged stay in the hospital (<jats:italic>p<\/jats:italic>\u2009=\u2009.00).\u00a0Lymphocyte count less than 20% and chest CT scan findings with more than 50% involvement might be related to the patient's mortality. These could act as laboratory and clinical indicators of disease severity, mortality, and outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27060","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T16:39:46Z","timestamp":1620146386000},"page":"5425-5431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lymphopenia and lung complications in patients with coronavirus disease\u20102019 (COVID\u201019): A retrospective study based on clinical data"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4009-717X","authenticated-orcid":false,"given":"Ehsan","family":"Zaboli","sequence":"first","affiliation":[{"name":"Gastrointestinal Cancer Research Center, Non\u2010Communicable Diseases Institute Mazandaran University of Medical Sciences  Sari 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